NMR Systems Upgrade for a Sustainable New Era
核磁共振系统升级,迎接可持续发展的新时代
基本信息
- 批准号:RTI-2020-00491
- 负责人:
- 金额:$ 10.93万
- 依托单位:
- 依托单位国家:加拿大
- 项目类别:Research Tools and Instruments
- 财政年份:2019
- 资助国家:加拿大
- 起止时间:2019-01-01 至 2020-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Eight NMR instruments are housed in the Chemistry Department of McGill University and supports the training and research of more than 300 Chemistry HQPs per year in 32 different research groups in that Department. Additionally, there are many other HQPs and PIs from other departments at McGill and other academic institutions within Canada whose research requires the use of these NMR instruments. Therefore, the Helium Recovery Instrument requested by the five co-applicants of this NSERC RTI is submitted on behalf of all the users of the NMR instruments in the Chemistry Department of McGill University. The instrument requested is a necessary upgrade for a sustainable new era in NMR studies, and will allow the optimal use of the PIs' NSERC Discovery Grants for maximum research productivity and HQP training.******Examples of research applications from the five co-applicants include the general use of NMR for characterization of small molecules, characterization of biomolecular interactions with small ligands and mechanistic studies for understanding catalytic transformations. Arndtsen's research focuses on the development of new transition metal catalyzed reactions, which range from metal catalyzed, bond-forming chemistry, multicomponent coupling reactions, to C-H bond functionalizations. As such, his HQPs rely exclusively upon the use of NMR analysis for monitoring reactions and catalyst development. Gleason's research focuses on novel organocatalysts for a range of synthetic transformations, such as polyene cyclizations, oxy-Cope and cycloaddition chemistry. His studies include exploring the fundamental underlying mechanisms, which requires careful kinetic analysis, including 13C isotope experiments, that make extensive use of high-field NMR. Li's research focuses on unconventional and novel chemical transformations that can change the efficiency of chemical synthesis into more Green and Sustainable Chemistry. Each one of his research projects involves extensive liquid and solid-state NMR characterization of compounds and use of NMR for mechanistic studiers. Tsantrizos' research aims to exploit the molecular recognition elements affecting enzymatic and chemically-mediated catalytic processes. Her group is designing phosphorus-containing molecules that can be used as enzyme inhibitors and as ligands in metal-mediated and organocatalytic asymmetric synthesis. In the course of these investigations, NMR studies are required to elucidate the enzyme-bound conformation of ligands and catalyst-substrate interactions. Trempe's investigations focus on elucidating protein-protein interactions involving PINK1 and Parkin, two proteins that work together in a mitochondrial quality control pathway implicated in Parkinson's disease. His investigations require extensive NMR HSQC titration experiments using 15N- and 13C- labeled proteins and high-field spectrometers. **
八台核磁共振仪器被安置在麦吉尔大学化学系,并支持该部门32个不同研究小组每年300多名化学HQP的培训和研究。此外,还有许多来自麦吉尔大学其他部门和加拿大其他学术机构的其他HQP和PI,他们的研究需要使用这些NMR仪器。因此,本NSERC RTI的五个共同申请人所要求的氦回收仪器代表麦吉尔大学化学系NMR仪器的所有用户提交。所要求的仪器是核磁共振研究可持续发展新时代的必要升级,并将允许最佳使用PI的NSERC发现赠款,以最大限度地提高研究生产力和HQP培训。来自五个共同申请人的研究应用的例子包括NMR用于表征小分子的一般用途、表征生物分子与小配体的相互作用以及用于理解催化转化的机理研究。Arbrossen的研究重点是新的过渡金属催化反应的发展,范围从金属催化,键形成化学,多组分偶联反应,C-H键官能化。因此,他的HQP完全依赖于使用NMR分析来监测反应和催化剂开发。格里森的研究重点是一系列合成转化的新型有机催化剂,如多烯环化,氧Cope和环加成化学。他的研究包括探索基本的潜在机制,这需要仔细的动力学分析,包括13 C同位素实验,广泛使用高场NMR。李的研究重点是非常规和新颖的化学转化,可以改变化学合成的效率,使其成为更加绿色和可持续的化学。他的每一个研究项目都涉及化合物的广泛的液体和固体NMR表征以及NMR在机械研究中的应用。Tsantrizos的研究旨在利用影响酶和化学介导的催化过程的分子识别元件。她的研究小组正在设计含磷分子,这些分子可用作酶抑制剂和金属介导和有机催化不对称合成中的配体。在这些调查的过程中,NMR研究需要阐明酶结合的配体和催化剂-底物相互作用的构象。Trempe的研究重点是阐明涉及PINK 1和Parkin的蛋白质-蛋白质相互作用,这两种蛋白质在与帕金森病有关的线粒体质量控制途径中共同发挥作用。他的研究需要广泛的NMR HSQC滴定实验,使用15 N和13 C标记的蛋白质和高场光谱仪。**
项目成果
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Tsantrizos, Youla其他文献
Discovery of BI 224436, a Noncatalytic Site Integrase Inhibitor (NCINI) of HIV-1
- DOI:
10.1021/ml500002n - 发表时间:
2014-04-01 - 期刊:
- 影响因子:4.2
- 作者:
Fader, Lee D.;Malenfant, Eric;Tsantrizos, Youla - 通讯作者:
Tsantrizos, Youla
Tsantrizos, Youla的其他文献
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{{ truncateString('Tsantrizos, Youla', 18)}}的其他基金
Engineering Phosphorus-Containing Molecules as Leads for Medicinal Chemistry and as Tools for Asymmetric Synthesis
工程化含磷分子作为药物化学的先导化合物和不对称合成的工具
- 批准号:
RGPIN-2020-04049 - 财政年份:2022
- 资助金额:
$ 10.93万 - 项目类别:
Discovery Grants Program - Individual
Engineering Phosphorus-Containing Molecules as Leads for Medicinal Chemistry and as Tools for Asymmetric Synthesis
工程化含磷分子作为药物化学的先导化合物和不对称合成的工具
- 批准号:
RGPIN-2020-04049 - 财政年份:2021
- 资助金额:
$ 10.93万 - 项目类别:
Discovery Grants Program - Individual
Engineering Phosphorus-Containing Molecules as Leads for Medicinal Chemistry and as Tools for Asymmetric Synthesis
工程化含磷分子作为药物化学的先导化合物和不对称合成的工具
- 批准号:
RGPIN-2020-04049 - 财政年份:2020
- 资助金额:
$ 10.93万 - 项目类别:
Discovery Grants Program - Individual
Chemical Biology and Early Stages of Drug Discovery
化学生物学和药物发现的早期阶段
- 批准号:
RGPIN-2015-05529 - 财政年份:2019
- 资助金额:
$ 10.93万 - 项目类别:
Discovery Grants Program - Individual
Chemical Biology and Early Stages of Drug Discovery
化学生物学和药物发现的早期阶段
- 批准号:
RGPIN-2015-05529 - 财政年份:2018
- 资助金额:
$ 10.93万 - 项目类别:
Discovery Grants Program - Individual
Chemical Biology and Early Stages of Drug Discovery
化学生物学和药物发现的早期阶段
- 批准号:
RGPIN-2015-05529 - 财政年份:2017
- 资助金额:
$ 10.93万 - 项目类别:
Discovery Grants Program - Individual
Chemical Biology and Early Stages of Drug Discovery
化学生物学和药物发现的早期阶段
- 批准号:
RGPIN-2015-05529 - 财政年份:2016
- 资助金额:
$ 10.93万 - 项目类别:
Discovery Grants Program - Individual
Chemical Biology and Early Stages of Drug Discovery
化学生物学和药物发现的早期阶段
- 批准号:
RGPIN-2015-05529 - 财政年份:2015
- 资助金额:
$ 10.93万 - 项目类别:
Discovery Grants Program - Individual
Design and synthesis of molecular tools that modulate metabolic pathways- implications for drug discovery
调节代谢途径的分子工具的设计和合成——对药物发现的影响
- 批准号:
121762-2010 - 财政年份:2014
- 资助金额:
$ 10.93万 - 项目类别:
Discovery Grants Program - Individual
Design and synthesis of molecular tools that modulate metabolic pathways- implications for drug discovery
调节代谢途径的分子工具的设计和合成——对药物发现的影响
- 批准号:
121762-2010 - 财政年份:2013
- 资助金额:
$ 10.93万 - 项目类别:
Discovery Grants Program - Individual
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