Loading of native and modified phytoglycogen nanoparticles: fundamental studies to improve the solubilization, stabilization and delivery of bioactive molecules

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The use of molecules from nature in nanotechnology applications provides unique opportunities to achieve safety and sustainability. This is particularly promising when enhanced performance and efficacy is achieved, providing a competitive advantage over artificial or engineered nanomaterials. The proposed research investigates applications of one such promising natural nanotechnology: the natural, sustainable and safe PhytoSpherix (Phx) technology. The Phx particles, extracted and purified from sweet corn, are being commercialized by our partner company, Mirexus Biotechnologies Inc., an emerging Canadian company that is a world leader in personal care applications of Phx. We will investigate new, very promising applications in the solubilisation, stabilization and delivery of bioactive molecules such as flavours, colours and drugs for use in cosmetics, nutrition and biomedicine. The academic research team will use a wide range of experimental techniques, and their unique expertise in the study of biological soft materials and the interaction of bioactives with cells, to address the following questions: 1) Can the bioactive molecules penetrate the highly branched, dense Phx particles? 2) How strongly are the bioactive molecules bound to the Phx particles? 3) What are the best environmental conditions to enhance the loading or release of bioactive molecules? 4) Can modifications to the Phx particles be used to enhance their loading? 5) After bioactives are loaded into Phx particles, are they still biologically active? The answers to these fundamental questions, together with Mirexus' in-depth technical and market knowledge, should significantly accelerate the commercialization of new and improved nutraceutical and biomedical products based on the sustainable Phx technology. This will lead to significant benefits for Canada, ranging from the creation of jobs at Guelph-based Mirexus and other Canadian companies, to improved, natural and safe products for Canadian consumers and patients.