Epithelial Polarity and Development

上皮极性和发育

• 批准号: CRC-2016-00276
• 负责人: Tepass, Ulrich
• 金额: $ 14.57万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Canada Research Chairs
• 财政年份: 2019
• 资助国家: 加拿大
• 起止时间: 2019-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=694334
• 关键词: Epithelial; Polarity; Development

The epithelium is the most frequently encountered tissue in the human body and a central component of most organs. Defects in epithelial cells are the root cause of many diseases including more than 80% of all forms of cancer. All epithelial tissues share a polarized cell structure that is critical for their formation and function. Dr. Tepass investigates the mechanisms that regulate the formation and maintenance of epithelial polarity during development to better understand how growth of epithelial cells can be controlled in the context of regenerative medicine or to prevent the progression of cancer.

上皮是人体中最常见的组织，也是大多数器官的中心组成部分。上皮细胞的缺陷是许多疾病的根本原因，包括超过80%的所有形式的癌症。所有上皮组织都有一个极化的细胞结构，这对它们的形成和功能至关重要。Tepass博士研究了在发育过程中调节上皮极性形成和维持的机制，以更好地了解如何在再生医学的背景下控制上皮细胞的生长或预防癌症的进展。