Quantitative Magnetic Resonance Imaging

定量磁共振成像

• 批准号: 1000230815-2015
• 负责人: CohenAdad, Julien
• 金额: $ 4.37万
• 依托单位: École Polytechnique de Montréal
• 依托单位国家: 加拿大
• 项目类别: Canada Research Chairs
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=695609
• 关键词: Quantitative; Magnetic; Resonance; Imaging

Pathologies of the nervous central system can induce severe functional disabilities (e.g., paralysis). Unfortunately, clinicians lack objective tools to assess the microstructural damage to axons, preventing them from choosing the optimal treatment for their patients. While recent developments of quantitative MRI (qMRI) have shown strong potentials to characterize microstructure, these new techniques remain far from the clinic due to the lack of validation and challenges inherent to data acquisition and processing. The proposed Chair intends to develop state-of-the-art qMRI tools to precisely assess microstructural damage, which will in turn become essential for clinical evaluation and objective assessment of treatment efficiency.

神经中枢系统的病理可诱发严重的功能性残疾（例如，瘫痪）。不幸的是，临床医生缺乏客观的工具来评估轴突的微观结构损伤，这使他们无法为患者选择最佳治疗方法。虽然定量MRI（qMRI）的最新发展已经显示出表征微观结构的强大潜力，但由于缺乏数据采集和处理固有的验证和挑战，这些新技术仍然远离临床。拟议的主席打算开发最先进的qMRI工具，以精确评估微结构损伤，这反过来将成为临床评价和客观评估治疗效率的关键。