Novel hybrid coils for real-time artifact suppression in magnetic resonance imaging

用于磁共振成像实时伪影抑制的新型混合线圈

• 批准号: 526583-2018
• 负责人: CohenAdad, Julien
• 金额: $ 1.82万
• 依托单位: École Polytechnique de Montréal
• 依托单位国家: 加拿大
• 项目类别: Engage Grants Program
• 财政年份: 2018
• 资助国家: 加拿大
• 起止时间: 2018-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=647889
• 关键词: Novel; hybrid; coils; real; time

Magnetic resonance imaging (MRI) of monkeys is useful to further understanding the healthy and pathological**brain and come up with new treatments for stroke, traumatic brain injuries and neurodegenerative diseases. The**Canadian company Rogue-Research (RR) is a leader in the field of monkey MRI and it engages in various**international collaborations with industrial and academic partners. RR is well-known for their 3D**neuro-navigation system (Brainsight) as well as for the MRI-compatible chair for imaging awake monkeys.**One remaining challenge however is the absence of a radiofrequency coil that is mechanically compatible with**the RR chair. A radiofrequency (or RF) coil is an essential part of an MRI system and is used to record signal**from the brain water molecules, allowing us to reconstruct 3D images of the brain. In addition, imaging**monkeys is challenging, notably because the thickness of their skull and the close proximity of the sinuses to**key regions in the brain produce MRI strong image distortions and signal loss, which are detrimental for the**interpretation of the MRI data. The lab of Dr. Cohen-Adad has been developing innovative RF coils which are**optimized to the structure of interest (here, the monkey's head), which are capable to adapt to any mechanical**structure, and more importantly, which feature a hybrid electronic circuit used to send continuous current in**order to compensate for magnetic field inhomogeneities responsible for the image distortions and signal loss**mentioned above. In this project, we propose to initiate a partnership between the lab of Dr. Cohen-Adad and**RR. The main objective is to design and build an MRI coil prototype, which is compatible with the RR monkey**chair and which features the novel hybrid technology for simultaneous acquisition and artifact compensation.**We anticipate this novel technology will enable researchers to image awake monkeys with unprecedented**image quality and will attract MRI manufacturers for developing similar applications in humans.

猴子的磁共振成像（MRI）有助于进一步了解健康和病理性大脑，并为中风，创伤性脑损伤和神经退行性疾病提供新的治疗方法。** 加拿大Rogue-Research公司（RR）是猴子MRI领域的领导者，它与工业和学术合作伙伴进行各种 ** 国际合作。RR以其3D** 神经导航系统（Brainsight）以及用于成像清醒猴子的MRI兼容椅子而闻名。然而，剩下的一个挑战是缺乏与RR椅机械兼容的射频线圈。射频（或RF）线圈是MRI系统的重要组成部分，用于记录来自大脑水分子的信号 **，使我们能够重建大脑的3D图像。此外，对 ** 猴子进行成像也是一项挑战，特别是因为它们头骨的厚度和鼻窦与大脑中 ** 关键区域的紧密接近会产生MRI强烈的图像失真和信号丢失，这对MRI数据的解释是不利的。Cohen-Adad博士的实验室一直在开发创新的RF线圈，这些线圈针对感兴趣的结构（这里是猴子的头部）进行了优化，能够适应任何机械结构，更重要的是，它具有用于发送连续电流的混合电子电路，以补偿磁场不均匀性，从而导致上述图像失真和信号丢失。在这个项目中，我们建议在Cohen-Adad博士的实验室和 **RR之间建立伙伴关系。主要目标是设计和构建一个MRI线圈原型，该原型与RR猴 ** 椅兼容，并具有用于同时采集和伪影补偿的新型混合技术。**我们预计这项新技术将使研究人员能够以前所未有的图像质量对清醒的猴子进行成像，并将吸引MRI制造商在人类身上开发类似的应用。