Organic Chemistry

有机化学

• 批准号: 1000233058-2019
• 负责人: Rousseaux, Sophie
• 金额: $ 1.82万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Canada Research Chairs
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=696087
• 关键词: Organic; Chemistry

Over the last century, impressive developments in transition metal-catalysis have enabled the production of molecules in our everyday lives, including medicines, plastics, and food. Our needs are now shifting towards the development of more efficient processes for their preparation, from both an environmental and economic point of view. Dr. Sophie Rousseaux leads an internationally recognized research program focused on using earth-abundant and inexpensive nickel catalysts to efficiently prepare value-added products from abundant feedstocks. The proposed research program aims to explore the reactivity of new redox-active alcohol derivatives in Ni-catalyzed cross-couplings with a focus on the synthesis of pharmaceutically-relevant molecules.

在上个世纪，过渡金属催化的令人印象深刻的发展使我们日常生活中的分子，包括药物，塑料和食品的生产成为可能。从环境和经济的角度来看，我们现在的需求正在转向开发更有效的制备方法。Sophie Rousseaux博士领导着一个国际公认的研究项目，专注于使用地球上丰富而廉价的镍催化剂，从丰富的原料中有效地制备增值产品。拟议的研究计划旨在探索新的氧化还原活性醇衍生物在镍催化的交叉偶联反应中的反应性，重点是药物相关分子的合成。