High Resolution Structure of Human ABCA4, an ATP-binding Cassette (ABC) Lipid Importer Associated with Inherited Retinal Degenerative Diseases

人类 ABCA4 的高分辨率结构，一种与遗传性视网膜退行性疾病相关的 ATP 结合盒 (ABC) 脂质输入蛋白

• 批准号: 433524
• 负责人: Molday Robert S
• 金额: $ 66.88万
• 依托单位: University of British Columbia
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-10-01 至 2025-10-01
• 项目状态: 未结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=433524&lang=en
• 关键词: Abc Transporter; Atpase Assays; Conformational States; Cryo-Electron Microscopy; Lipid Transport; Macular Degeneration; Photoreceptor Cells; Protein Expression And Purification; Protein Structure; Site-Directed Mutagenesis

Inherited retinal degenerative diseases are a heterogeneous group of disorders that are a major cause of blindness in the world population. They typically result in progressive loss in vision due to mutations in genes encoding proteins essential for the f

遗传性视网膜变性疾病是一组异质性疾病，是世界人口失明的主要原因。它们通常会导致视力的进行性丧失，这是由于基因编码的蛋白质发生突变，而这些蛋白质是视网膜病变的关键。