Structural basis and mechanism of BAP1 ubiquitination and tumor suppressor regulation by the E2/E3 hybrid enzyme UBE2O

BAP1泛素化和E2/E3杂合酶UBE2O抑癌调节的结构基础和机制

• 批准号: 440448
• 负责人: Daou Salima
• 金额: $ 3.28万
• 依托单位: Sinai Health System (Toronto)
• 依托单位国家: 加拿大
• 项目类别: Fellowship Programs
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-12-01 至 2021-12-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=440448&lang=en
• 关键词: Cellular Biology; Cryo-Electron Microscopy (Cryo-Em); Deubiquitinases; Drug Discovery; Structural Biology; Ubiquitin Conjugating Enzyme (E2); Ubiquitin Ligase (E3); Ubiquitin Proteasome System (Ups); X-Ray Crystallography

The well-orchestrated functioning of our cells is under the control of a multitude of devices called proteins. In our body, our cells destroy damaged or unwanted proteins using a highly complex protein degradation process called the Ubiquitin Proteasome S

我们细胞的精心策划的功能是在大量称为蛋白质的设备的控制下。在我们的身体里，我们的细胞通过一种叫做泛素蛋白酶体S的高度复杂的蛋白质降解过程来破坏受损或不需要的蛋白质。