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Structural basis and mechanism of BAP1 ubiquitination and tumor suppressor regulation by the E2/E3 hybrid enzyme UBE2O

Structural basis and mechanism of BAP1 ubiquitination and tumor suppressor regulation by the E2/E3 hybrid enzyme UBE2O
BAP1泛素化和E2/E3杂合酶UBE2O抑癌调节的结构基础和机制
批准号：
440448
负责人：
Daou Salima
金额：
$3.28万
依托单位：
Sinai Health System (Toronto)
依托单位国家：
加拿大
项目类别：
Fellowship Programs
财政年份：
2020
资助国家：
加拿大
项目状态：
已结题
起止时间：
2020-12-01 至 2021-12-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=440448&lang=en
关键词：
Cellular Biology Cryo-Electron Microscopy (Cryo-Em) Deubiquitinases Drug Discovery Structural Biology Ubiquitin Conjugating Enzyme (E2) Ubiquitin Ligase (E3) Ubiquitin Proteasome System (Ups) X-Ray Crystallography

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中文摘要
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英文摘要
The well-orchestrated functioning of our cells is under the control of a multitude of devices called proteins. In our body, our cells destroy damaged or unwanted proteins using a highly complex protein degradation process called the Ubiquitin Proteasome S
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Assembly, activation and function of BRISC deubiquitinase complexes
Assembly, activation and function of BRISC deubiquitinase complexes
  • 批准号：
    361711
  • 项目类别：
    Fellowship Programs
  • 资助金额：
    $9.83万
  • 财政年份：
    2016
  • 负责人：
    Daou Salima
  • 依托单位：
    Sinai Health System (Toronto)
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