Assembly, activation and function of BRISC deubiquitinase complexes

BRISC 去泛素酶复合物的组装、激活和功能

• 批准号: 361711
• 负责人: Daou Salima
• 金额: $ 9.83万
• 依托单位: Sinai Health System (Toronto)
• 依托单位国家: 加拿大
• 项目类别: Fellowship Programs
• 财政年份: 2016
• 资助国家: 加拿大
• 起止时间: 2016-11-01 至 2019-11-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=361711&lang=en
• 关键词: Cell Signaling; Cellular Biology; Cryo-Electron Microscopy (Cryo-Em); Deubiquitinases; Drug Discovery; Jamm/Mpn Family Deubiquitinases; Nuclear Magnetic Resonance Spectroscopy (Nmr); Structural Biology; Ubiquitin Proteasome System (Ups); X-Ray Crystallogr

Our cells decompose damaged or unwanted proteins using a highly complex protein degradation system. Specifically, cells possess protein machines also called enzymes (more specifically ubiquitin ligases) that mediate the attachment of a small protein calle

我们的细胞使用高度复杂的蛋白质降解系统分解受损或不需要的蛋白质。具体来说，细胞拥有蛋白质机器，也称为酶（更具体地说是遍在蛋白连接酶），可以介导小蛋白质细胞的附着