100-Patient Ventilator for COVID-19

对于那些受冠状病毒影响最大的患者，机械通风是必不可少的。在加拿大和世界上大多数国家，可用的呼吸机供应量与预计需求量之间的差距为1-2个数量级。短缺是极端的。虽然与药物和疫苗相关的时间表还不确定，但患病人数和需要机械通风的人数越来越确定。世界各地正在进行许多提供呼吸机的努力，我们在一个可共享的储存库中提供了对当前努力的全面审查。目前努力的关键挑战是，每个患者一个系统的方法将不会在数量、能力或可靠性方面扩大规模。问题的关键是，每个患者一个系统的模式已经被打破，但重要的患者定制是必不可少的。我们聘请了团队成员兼呼吸专家Ewan Goligher为患者提供最低限度的通风要求，并共同制定了这一挑战：一个系统如何在满足患者需求和安全的同时，为多名患者提供必要的床边定制？我们的解决方案--可容纳100名患者的新冠肺炎呼吸机--采用了集中的气体处理方式，并在床边提供必要的气体控制。基本的患者可定制的操作参数通过一个简单的流体控制单元进行设置。这种方法提高了集中式设施的有效性和效率，并降低了成本和复杂性。受在建的可容纳90-100名患者的Joseph Brant野战医院的启发，我们为100名患者设计了我们的系统，这些系统将连接在10个系列的10个呼吸机中-所有这些都由一个中央气体调节系统提供服务。这里的预算将用于开发、建造和测试2个串，每个串有10个患者单元，以及一个可容纳100名患者的中央系统。随着这一试点在2020年初取得成功，我们将有潜力在这次疫情中进行合作和扩大规模，以产生重大影响。 随着这一试点在2020年初取得成功，我们将有可能在这次疫情中产生重大影响。

Mechanical ventilation is essential for the treatment of those most effected by coronavirus. The gap between the available supply of ventilators and the projected demand - in Canada and most countries worldwide - is 1-2 orders of magnitude. The shortage is extreme. While the timelines associated with drugs and vaccines are uncertain, the number of sick and the number in need of mechanical ventilation is increasingly certain. Many efforts are underway worldwide to provide ventilators, and we provide a comprehensive review of current efforts in a shareable repository. The key challenge with current efforts is that the one-system-per-patient approach will not scale in number, capability or reliability. The crux of the issue is that the one-system-per-patient model is broken, yet significant patient-customization is essential. We engaged team member and respiratory specialist Ewan Goligher to provide the absolute minimum requirements for patient ventilation and together formulated this challenge: How can one system provide for many patients, while enabling the essential at-bedside customization for patient needs and safety? Our solution - a 100-Patient Ventilator for COVID-19 - levers centralized gas processing and provides the essential gas control at the bedside. The essential patient-customizable operating parameters are set via a simple fluid control unit. This approach levers the effectiveness and efficiency of centralized facilities, and reduces cost and complexity. Inspired by the Joseph Brant field hospital under construction with capacity for 90-100 patients, we designed our system for 100 patients that will be connected in 10 strings of 10 ventilators - all served by a centralized gas conditioning system. The budget here will enable the development, building and testing of 2 strings with 10 patient units each, and a central system with capacity for 100 patients. With success of this pilot in early 2020, we will have the potential to partner and scale for major impact in this outbreak. With success of this pilot in early 2020, we will have the potential to make a major impact in this outbreak.