Novel Regulatory Roles of the Evolutionarily Conserved Drosha dsRNA ribonuclease

进化保守的 Drosha dsRNA 核糖核酸酶的新调控作用

• 批准号: 440629
• 负责人: Yague-Sanz Carlo
• 金额: $ 6.56万
• 依托单位: Universit de Sherbrooke
• 依托单位国家: 加拿大
• 项目类别: Fellowship Programs
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-12-01 至 2022-12-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=440629&lang=en
• 关键词: Molecular Genetics; Rna; Transcription

Drosha is a conserved ribonuclease that cleaves stem-loop RNA structures and is well-known for its role in microRNA (miRNA) biogenesis. However, Drosha has recently been shown to cleave non-miRNA targets, influencing RNA stability and/or transcription ter

Drosha是一种保守的核糖核酸酶，切割茎环RNA结构，并以其在微小RNA（miRNA）生物发生中的作用而闻名。然而，Drosha最近被证明可以切割非miRNA靶点，影响RNA稳定性和/或转录因子。