Exploring the role of lipid transfer at the mitochondria-lysosome contact sites in the regulation of mitochondrial shape and function

探索线粒体-溶酶体接触位点的脂质转移在线粒体形状和功能调节中的作用

• 批准号: 441083
• 负责人: Boutry Maxime
• 金额: $ 9.83万
• 依托单位: Hospital for Sick Children (Toronto)
• 依托单位国家: 加拿大
• 项目类别: Fellowship Programs
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-12-01 至 2023-12-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=441083&lang=en
• 关键词: Lipid Transfer Proteins; Lysosomes; Membrane Contact Sites; Mitochondria; Mitochondrial Dynamics; Neurological Diseases

Mitochondria are essential cellular organelles that are often defined as the powerhouse of the cell. Their morphology is strongly linked to their functions and can be modulated through fission or fusion. Notably, it was shown that intricate contact with o

线粒体是重要的细胞器，通常被定义为细胞的动力源。它们的形态与它们的功能密切相关，可以通过分裂或融合来调节。值得注意的是，研究表明，与O的复杂接触