Microglial lysosomes and selective neuronal vulnerability

小胶质细胞溶酶体和选择性神经元脆弱性

基本信息

项目摘要

Project Summary Microglial responses to aging are associated with substantive rearrangements in lysosome abundance, size, subcellular localization, as well as changes in the expression of numerous genes associated with lysosome function. Our group has recently shown that these microglial aging phenotypes emerge with pronounced regional specificity, with the ventral tegmental area (VTA) and substantia nigra pars compacta (SNc) microglia showing these changes by early middle age. With support from our parent R01, we are working to determine how these changes in microglial lysosome networks shape synapse-relevant microglial attributes and impact synapse integrity and neuronal excitability, which have been shown to be robust contributors to age-associated cognitive decline. The goal of the current diversity supplement is to support the career advancement of Ms Abigail Gutierrez through postbaccalaureate training and research aimed at directly probing relationships between microglial lysosome status and cognitive function in aging mice. During her undergraduate training at UCLA, Ms Gutierrez worked together with a postdoctoral fellow to develop a reward-based foraging task and showed that this task is sensitive to subtle changes in reward-based memory in late middle age, wild-type mice. Continued postbaccalaureate training in the lab will allow Ms Gutierrez to expand her scientific and professional skills in critical ways toward her goal of entering an MD/PhD program and becoming an independent physician-scientist. Abigail will gain essential skills in immunostaining, high resolution confocal microscopy and image analysis by carrying out immunohistochemistry to analyze microglial lysosomes in behaviorally-characterized young adult and aging mice. She will learn mouse husbandry, genotyping, and will further expand her skills in mouse behavior by running cohorts of mice with genetic manipulations of microglial lysosome status through the reward-based foraging task. Abigail will improve her independence, writing, and presentation skills through in-person and online classes, assisting with manuscript preparation, and sharing her research at international conferences. We have assembled an excellent mentoring team and mapped out milestones that render this period of postbaccalaureate training similar to a degree-granting masters program. This proposal will advance the career of an exceptional young scientist and allow her to show whether aging associated rearrangements in VTA and SNC microglial lysosomes represent a vulnerability in the aging brain, or a more adaptive response that helps sustain neuronal circuits and cognitive function later in the lifespan.
项目总结

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Lindsay Mitchell De Biase其他文献

Lindsay Mitchell De Biase的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Lindsay Mitchell De Biase', 18)}}的其他基金

Microglial lysosomes and selective neuronal vulnerability
小胶质细胞溶酶体和选择性神经元脆弱性
  • 批准号:
    10599106
  • 财政年份:
    2022
  • 资助金额:
    $ 4.99万
  • 项目类别:
Microglial lysosomes and selective neuronal vulnerability
小胶质细胞溶酶体和选择性神经元脆弱性
  • 批准号:
    10345614
  • 财政年份:
    2022
  • 资助金额:
    $ 4.99万
  • 项目类别:

相似海外基金

THE GENETICS AND FUNCTIONAL NEUROANATOMY OF AGE-ASSOCIATED MEMORY IMPAIRMENT
年龄相关记忆障碍的遗传学和功能神经解剖学
  • 批准号:
    7606738
  • 财政年份:
    2007
  • 资助金额:
    $ 4.99万
  • 项目类别:
THE GENETICS AND FUNCTIONAL NEUROANATOMY OF AGE-ASSOCIATED MEMORY IMPAIRMENT
年龄相关记忆障碍的遗传学和功能神经解剖学
  • 批准号:
    7717960
  • 财政年份:
    2007
  • 资助金额:
    $ 4.99万
  • 项目类别:
THE GENETICS AND FUNCTIONAL NEUROANATOMY OF AGE-ASSOCIATED MEMORY IMPAIRMENT
年龄相关记忆障碍的遗传学和功能神经解剖学
  • 批准号:
    7205360
  • 财政年份:
    2004
  • 资助金额:
    $ 4.99万
  • 项目类别:
CITICOLINE AND AGE ASSOCIATED MEMORY IMPAIRMENT
胞二磷胆碱与年龄相关的记忆障碍
  • 批准号:
    6305687
  • 财政年份:
    1999
  • 资助金额:
    $ 4.99万
  • 项目类别:
CITICOLINE AND AGE ASSOCIATED MEMORY IMPAIRMENT
胞二磷胆碱与年龄相关的记忆障碍
  • 批准号:
    6115572
  • 财政年份:
    1998
  • 资助金额:
    $ 4.99万
  • 项目类别:
A study on the biological features of age-associated memory impairment (AAMI).
年龄相关记忆障碍(AAMI)生物学特征的研究。
  • 批准号:
    09671003
  • 财政年份:
    1997
  • 资助金额:
    $ 4.99万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C).
CITICOLINE AND AGE ASSOCIATED MEMORY IMPAIRMENT
胞二磷胆碱与年龄相关的记忆障碍
  • 批准号:
    6276806
  • 财政年份:
    1997
  • 资助金额:
    $ 4.99万
  • 项目类别:
AGE-ASSOCIATED MEMORY IMPAIRMENT: COMMUNITY-BASED STUDY
与年龄相关的记忆障碍:基于社区的研究
  • 批准号:
    3386469
  • 财政年份:
    1990
  • 资助金额:
    $ 4.99万
  • 项目类别:
AGE-ASSOCIATED MEMORY IMPAIRMENT: COMMUNITY-BASED STUDY
与年龄相关的记忆障碍:基于社区的研究
  • 批准号:
    3386468
  • 财政年份:
    1990
  • 资助金额:
    $ 4.99万
  • 项目类别:
AGE-ASSOCIATED MEMORY IMPAIRMENT: COMMUNITY-BASED STUDY
与年龄相关的记忆障碍:基于社区的研究
  • 批准号:
    3386465
  • 财政年份:
    1990
  • 资助金额:
    $ 4.99万
  • 项目类别:
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了