Rapid Reagent-Free Detection of COVID-19 in Exhaled Breath Condensate using Ultra-Sensitive Multi-wavelength SERS Nano-gratings
使用超灵敏多波长 SERS 纳米光栅快速无试剂检测呼出气体冷凝物中的 COVID-19
基本信息
- 批准号:554955-2020
- 负责人:
- 金额:$ 3.64万
- 依托单位:
- 依托单位国家:加拿大
- 项目类别:Alliance Grants
- 财政年份:2020
- 资助国家:加拿大
- 起止时间:2020-01-01 至 2021-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
As the third documented emergence of an animal-to-human coronavirus during the past two decades (Severe Acute Respiratory Syndrome in 2002, Middle East Respiratory Syndrome in 2012), the current pandemic and near-certainty of future epidemics demands intensified surveillance and proactive screening. Definitive therapy for novel Coronavirus Disease 2019 (COVID-19) is likely at least a year away. Current standard-of-care diagnostic testing with real-time Reverse Transcription Polymerase Chain Reaction (rRT-PCR) is resource intensive, costly and inaccurate. An alternative, high sensitivity, rapid and label-free technique for detecting and differentiating molecular structures, including viral strains, at the point-of-testing is urgently needed.
Since 2014, Professor Kherani's team at the University of Toronto (UofT) has been developing a novel nanophotonic sensing (NPS) platform to detect disease biomarkers with unprecedented sensitivity. This patented technology platform will be repurposed to develop a high sensitivity, rapid near-instantaneous, reagent-free point-of-care testing (PoCT) system for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). We (engineering, medicine, and industry) collaboratively propose to demonstrate the viability of rapid reagent-free detection of COVID-19 in exhaled breath condensate (EBC) and allied samples using ultra-sensitive multi-wavelength SERS nano-gratings technology, and further, translate this technology for widespread use in a range of public and health settings. Deployment of the EBC Analyzer will improve COVID-19 containment protocols, facilitating rapid positive-case identification in hospitals, nursing homes and the community at large (schools, offices, factories and transportation hubs) and will allow for future disease surveillance.
作为过去20年中第三次记录到的动物到人的冠状病毒(2002年的严重急性呼吸系统综合征,2012年的中东呼吸系统综合征),目前的大流行和未来流行病的几乎确定性要求加强监测和主动筛查。2019年新型冠状病毒病(COVID-19)的持续治疗可能至少需要一年时间。目前使用实时逆转录聚合酶链反应(rRT-PCR)的标准护理诊断测试是资源密集型的,昂贵且不准确。迫切需要一种替代的、高灵敏度、快速和无标记的技术,用于在测试点检测和区分分子结构,包括病毒株。
自2014年以来,多伦多大学(UofT)的Kherani教授团队一直在开发一种新型的纳米光子传感(Nanophotonic Sensing,简称MEMS)平台,以前所未有的灵敏度检测疾病生物标志物。该专利技术平台将被重新用于开发针对严重急性呼吸系统综合征冠状病毒2(SARS-CoV-2)的高灵敏度,快速近即时,无试剂的即时检测(PoCT)系统。我们(工程,医学和工业)合作提出使用超灵敏多波长Sers纳米光栅技术来证明呼出气冷凝液(EBC)和相关样品中COVID-19快速无试剂检测的可行性,并进一步将该技术转化为广泛用于一系列公共和卫生环境。EBC分析仪的部署将改进COVID-19遏制方案,促进医院、养老院和整个社区(学校、办公室、工厂和交通枢纽)快速识别阳性病例,并将允许未来的疾病监测。
项目成果
期刊论文数量(0)
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Kherani, Nazir其他文献
Kherani, Nazir的其他文献
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{{ truncateString('Kherani, Nazir', 18)}}的其他基金
Novel on-chip UV absorption spectrometer using electrically tunable photodetector
使用电可调光电探测器的新型片上紫外吸收光谱仪
- 批准号:
530252-2018 - 财政年份:2021
- 资助金额:
$ 3.64万 - 项目类别:
Collaborative Research and Development Grants
Engineering New Nanostructured Materials for Tunable Light-Matter Interactions
工程新型纳米结构材料可调节光-物质相互作用
- 批准号:
RGPIN-2017-06405 - 财政年份:2021
- 资助金额:
$ 3.64万 - 项目类别:
Discovery Grants Program - Individual
Engineering New Nanostructured Materials for Tunable Light-Matter Interactions
工程新型纳米结构材料可调节光-物质相互作用
- 批准号:
RGPIN-2017-06405 - 财政年份:2020
- 资助金额:
$ 3.64万 - 项目类别:
Discovery Grants Program - Individual
Novel on-chip UV absorption spectrometer using electrically tunable photodetector
使用电可调光电探测器的新型片上紫外吸收光谱仪
- 批准号:
530252-2018 - 财政年份:2020
- 资助金额:
$ 3.64万 - 项目类别:
Collaborative Research and Development Grants
Next-Generation Point-of-Care System: Custom Integration of Confocal Raman Spectrometer and High-Sensitivity NanoPhotonic-MicroFluidic Devices
下一代护理点系统:共焦拉曼光谱仪和高灵敏度纳米光子微流体设备的定制集成
- 批准号:
RTI-2020-00629 - 财政年份:2019
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$ 3.64万 - 项目类别:
Research Tools and Instruments
Engineering New Nanostructured Materials for Tunable Light-Matter Interactions
工程新型纳米结构材料可调节光-物质相互作用
- 批准号:
RGPIN-2017-06405 - 财政年份:2019
- 资助金额:
$ 3.64万 - 项目类别:
Discovery Grants Program - Individual
Novel on-chip UV absorption spectrometer using electrically tunable photodetector
使用电可调光电探测器的新型片上紫外吸收光谱仪
- 批准号:
530252-2018 - 财政年份:2019
- 资助金额:
$ 3.64万 - 项目类别:
Collaborative Research and Development Grants
Engineering New Nanostructured Materials for Tunable Light-Matter Interactions
工程新型纳米结构材料可调节光-物质相互作用
- 批准号:
RGPIN-2017-06405 - 财政年份:2018
- 资助金额:
$ 3.64万 - 项目类别:
Discovery Grants Program - Individual
High energy-efficient UV lamps using nano-thin spectrally selective metallo-dielectric layers
使用纳米薄光谱选择性金属介电层的高能效紫外线灯
- 批准号:
531335-2018 - 财政年份:2018
- 资助金额:
$ 3.64万 - 项目类别:
Engage Grants Program
Novel on-chip UV absorption spectrometer using electrically tunable photodetector
使用电可调光电探测器的新型片上紫外吸收光谱仪
- 批准号:
530252-2018 - 财政年份:2018
- 资助金额:
$ 3.64万 - 项目类别:
Collaborative Research and Development Grants
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