Development and validation of a SARS-CoV-2 antiviral coatings for high-touch critical surfaces

这项研究集中在一个高度成本效益，生产准备的抗病毒涂层，可以大大降低SARS-CoV-2在高接触金属表面上的传播率，如果在配件上实施（例如门把手、楼梯扶手），管理机构已经认识到一系列铜（Cu）合金作为安全使用的材料，其表现出固有的宽在不到2小时的时间内，证明其在减少医院细菌污染和灭活包膜和无包膜RNA病毒方面均有效，达到99.9%。 用固体Cu/Cu合金广泛替代这种高接触表面将是昂贵的;我们建议使用Cu/Cu合金冷喷涂涂层。在涂层工艺中，冷喷涂是一种工业工艺，其被证明能够高效地施加铜涂层，该铜涂层表现出比其他类型的涂层工艺更优越的上级性能;我们的初步试验数据证明了在30分钟内灭活99.9%的人冠状病毒的效率，这表明与固体对应物或其他涂层技术相比，它可以赋予上级抗病毒性能。此外，在加拿大，围绕冷喷涂技术的整个价值链将从这项研究的成功中受益匪浅，并迅速部署这些涂层高接触表面配件，以帮助减少SARS-CoV-2的传播。 合作者包括麦吉尔大学（岳教授，PI）和NRC（Irissou博士），他们自2007年以来在NRC Boucherville组装了麦吉尔-NRC冷喷涂设施。麦吉尔艾滋病中心临时主任陈亮博士最近获得CIHR COVID-19资助，用于研究SARS-CoV-2的传播和致病性。 Luc Pouliot代表Polycontrols，一家专门从事冷喷涂工业应用的公司。 Hatch有限公司（Murray Pearson）参与公共基础设施的规划、开发、设计和升级，包括地铁、交通设施、机场航站楼、公共空间、土木工程和商业开发;其最终用户将从这一举措中受益匪浅。最后，Amir Nobari代表专业粉末制造商5 N Plus。

This research is centred on a highly cost-effective, production-ready antiviral coating that could massively reduce the rate of SARS-CoV-2 transmission on high touch metallic surfaces if implemented on accessories (e.g. door handles, stair rails) in public spaces such as hospitals, mass transit etc. Regulatory agencies already recognize a range of copper (Cu) alloys as safe-to-use materials exhibiting intrinsic broad-spectrum antimicrobial activity that proved to be efficient in both reducing contamination of nosocomial bacteria and inactivating enveloped and non-enveloped RNA viruses by 99.9% in less than 2 hours. Extensive replacement of such high touch surfaces by solid Cu/Cu alloys would be costly; we propose the use of Cu/Cu alloy cold spray coatings. Among coating processes, cold spray is an industrial process that proved to be highly efficient to apply copper coatings that exhibit superior properties to other type of coating processes; our initial trial data demonstrates the efficiency of inactivating 99.9% of human coronavirus in 30 minutes, suggesting that it could imparts superior antiviral properties compared to solid counterparts, or to other coating techniques. Moreover, there is an entire value chain in Canada around cold spray technology which will tremendously benefit from the success of this study, and rapidly deploy these coated high touch surface accessories to help reducing the spread of SARS-CoV-2. The collaborators comprise McGill University (Prof Yue, PI) and NRC (Dr. Irissou), who have assembled the McGill-NRC cold spray facility at NRC-Boucherville, operating since 2007. Dr. Chen Liang, the Interim Director of the McGill AIDS Centre, was recently awarded a CIHR COVID-19 grant to investigate SARS-CoV-2 transmission and pathogenicity. Luc Pouliot represents Polycontrols, a company that specialises in industrial applications of cold spray. Hatch Ltd. (Murray Pearson) is involved in planning, development, design and upgrading of public infrastructure, including subways, transit facilities, airport terminals, public spaces, civil works and commercial developments; their end users would benefit greatly from this initiative. Finally, Amir Nobari represents 5N Plus, a specialist powder manufacturer.