Development and validation of a SARS-CoV-2 antiviral coatings for high-touch critical surfaces

用于高接触关键表面的 SARS-CoV-2 抗病毒涂层的开发和验证

• 批准号: 554903-2020
• 负责人: Yue, Stephen
• 金额: $ 3.64万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Alliance Grants
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=705750
• 关键词: Development; validation; SARS; CoV; antiviral

This research is centred on a highly cost-effective, production-ready antiviral coating that could massively reduce the rate of SARS-CoV-2 transmission on high touch metallic surfaces if implemented on accessories (e.g. door handles, stair rails) in public spaces such as hospitals, mass transit etc. Regulatory agencies already recognize a range of copper (Cu) alloys as safe-to-use materials exhibiting intrinsic broad-spectrum antimicrobial activity that proved to be efficient in both reducing contamination of nosocomial bacteria and inactivating enveloped and non-enveloped RNA viruses by 99.9% in less than 2 hours. Extensive replacement of such high touch surfaces by solid Cu/Cu alloys would be costly; we propose the use of Cu/Cu alloy cold spray coatings. Among coating processes, cold spray is an industrial process that proved to be highly efficient to apply copper coatings that exhibit superior properties to other type of coating processes; our initial trial data demonstrates the efficiency of inactivating 99.9% of human coronavirus in 30 minutes, suggesting that it could imparts superior antiviral properties compared to solid counterparts, or to other coating techniques. Moreover, there is an entire value chain in Canada around cold spray technology which will tremendously benefit from the success of this study, and rapidly deploy these coated high touch surface accessories to help reducing the spread of SARS-CoV-2. The collaborators comprise McGill University (Prof Yue, PI) and NRC (Dr. Irissou), who have assembled the McGill-NRC cold spray facility at NRC-Boucherville, operating since 2007. Dr. Chen Liang, the Interim Director of the McGill AIDS Centre, was recently awarded a CIHR COVID-19 grant to investigate SARS-CoV-2 transmission and pathogenicity. Luc Pouliot represents Polycontrols, a company that specialises in industrial applications of cold spray. Hatch Ltd. (Murray Pearson) is involved in planning, development, design and upgrading of public infrastructure, including subways, transit facilities, airport terminals, public spaces, civil works and commercial developments; their end users would benefit greatly from this initiative. Finally, Amir Nobari represents 5N Plus, a specialist powder manufacturer.

这项研究的重点是一种高成本效益、可生产的抗病毒涂层，如果在医院、公共交通等公共场所的配件（如门把手、楼梯扶手）上实施，可以大幅降低SARS-CoV-2在高接触金属表面上的传播率。监管机构已经认可一系列铜（Cu）合金是安全使用的材料，具有固有的广谱抗菌活性，可有效减少医院细菌的污染，并在不到2小时的时间内使包膜和非包膜RNA病毒灭活99.9%。用固体Cu/Cu合金广泛替代这种高接触表面将是昂贵的；我们建议使用Cu/Cu合金冷喷涂涂层。在涂层工艺中，冷喷涂是一种工业工艺，被证明是高效的铜涂层，表现出优于其他类型涂层工艺的性能；我们的初步试验数据表明，在30分钟内灭活99.9%的人类冠状病毒的效率，表明与固体对应物或其他涂层技术相比，它可以赋予更好的抗病毒特性。此外，加拿大围绕冷喷涂技术有一个完整的价值链，这将极大地受益于这项研究的成功，并迅速部署这些涂层的高接触面配件，以帮助减少SARS-CoV-2的传播。合作者包括麦吉尔大学（Yue教授，PI）和NRC （Irissou博士），他们在NRC- boucherville组装了麦吉尔-NRC冷喷雾设备，自2007年以来一直运行。麦吉尔艾滋病中心临时主任陈亮博士最近获得了CIHR COVID-19拨款，用于调查SARS-CoV-2的传播和致病性。Luc Pouliot代表Polycontrols，一家专门从事冷喷涂工业应用的公司。Hatch Ltd. （Murray Pearson）从事公共基础设施的规划、开发、设计和升级，包括地铁、交通设施、机场航站楼、公共空间、土建工程和商业开发；它们的终端用户将从这一举措中受益匪浅。最后，Amir Nobari代表5N Plus，一家专业粉末制造商。