Design and validation of hemostatic surgical sutures

止血手术缝合线的设计和验证

• 批准号: 560902-2020
• 负责人: Li, Jianyu
• 金额: $ 2.19万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Alliance Grants
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=706995
• 关键词: Design; validation; hemostatic; surgical; sutures

Sutures are used by your doctor to close wounds to your skin or other tissues. Despite the extensive use, existing sutures are not perfect. For instance, it is difficult to achieve a perfect seal because small gaps often present at the suture roots, causing bleeding, leakage, and in some cases, infection. To develop better surgical sutures, this project is focused on the development of novel surgical sutures, called hemostatic sutures, which can actively promote blood clotting at the suture sites. By doing so, the sutures are anticipated to mitigate the bleeding during suturing, enable safer and faster surgery, and ultimately promote healing. Such materials would impact general surgical procedures, particularly cardiovascular surgery. This project will support an interdisciplinary team with expertise in materials, bioengineering and surgery. The team will extend the technologies recently developed with the FRQNT Team grant to developing the new hemostatic sutures. The economic benefits of this project could be substantial. The global market of suture materials is $6 billion USD and there are 485,000 inpatient surgeries in Canada alone. With extended scope with the project, the FRQNT grant could bring impacts in the areas of hemorrhage control and cardiovascular surgery, both of which affect millions of patients and face critical clinical needs of better surgical technologies.

缝合线是医生用来缝合皮肤或其他组织的伤口。尽管广泛使用，现有的缝合线并不完美。例如，很难实现完美的密封，因为缝线根部经常存在小间隙，导致出血、渗漏，在某些情况下还会导致感染。