Market Assessment of silicon photonics-based biosensor for disease detection

用于疾病检测的硅光子生物传感器的市场评估

• 批准号: 560504-2021
• 负责人: Chrostowski, Lukas
• 金额: $ 1.09万
• 依托单位: University of British Columbia
• 依托单位国家: 加拿大
• 项目类别: Idea to Innovation
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=707130
• 关键词: Market; Assessment; silicon; photonics; based

UBC researchers are developing a silicon photonic multiplexed sensor architecture that is based on a low-cost fixed-wavelength laser. In contrast to tunable lasers, fixed wavelength 1310 nm distributed feedback (DFB) lasers are much cheaper ($1 in high volume). We have also implemented a novel technique to use photonic wirebonding to couple the light from the laser to the silicon photonic circuit, thereby removing the expensive lenses and nanopositioning hardware. Due to the compatibility with complementary metal-oxide semiconductor (CMOS) foundry processes, silicon photonic integrated circuits (PICs) can be manufactured at high volume, with the potential for integrating electronics within the sensor. Moreover, the high refractive index (RI) contrast between silicon and the surrounding media enables the development of miniaturized compact sensing devices, sensitive to changes in the local RI within the evanescent field surrounding the device. Furthermore, a compact footprint of approximately 100 x 100 micron per device permits the fabrication of multiple sensors on one single chip, with each sensor having its own chemistry. Multiplexing many sensors, thereby being able to run multiple assays on a single chip, is the biggest advantage of silicon-based sensors over existing evanescent field detection methods, while offering a comparable limit of detection. This allows for measurements of several target entities for their specific molecular properties. For example, in biosensing, target analytes can be analyzed for several viral infections, with suitable controls, on the same sample of blood on the same chip. Silicon photonic sensors are excellent transducers for continuous and quantitative label-free biosensing, which can directly respond to affinity interactions between analyte and receptor molecules in real-time.

UBC的研究人员正在开发一种基于低成本固定波长激光器的硅光子多路复用传感器架构。与可调谐激光器相比，固定波长1310 nm分布反馈（DFB）激光器要便宜得多（大批量1美元）。我们还实现了一种新的技术，使用光子引线键合将激光器发出的光耦合到硅光子电路，从而消除了昂贵的透镜和纳米定位硬件。 由于与互补金属氧化物半导体（CMOS）铸造工艺的兼容性，硅光子集成电路（PIC）可以大批量制造，并有可能将电子器件集成到传感器内。此外，硅与周围介质之间的高折射率（RI）对比度使得能够开发小型化紧凑感测装置，其对装置周围的倏逝场内的局部RI的变化敏感。此外，每个器件大约100 × 100微米的紧凑占地面积允许在一个芯片上制造多个传感器，每个传感器都有自己的化学成分。多路复用许多传感器，从而能够在单个芯片上运行多个检测，这是硅基传感器相对于现有倏逝场检测方法的最大优势，同时提供了相当的检测极限。这允许测量几个目标实体的特定分子特性。例如，在生物传感中，可以在相同芯片上的相同血液样品上用合适的对照分析目标分析物的几种病毒感染。硅光子传感器是连续和定量的无标记生物传感的优秀传感器，它可以实时直接响应分析物和受体分子之间的亲和相互作用。