Effects of invertebrate neuropeptides and biogenic amines on synapses and behavior

无脊椎动物神经肽和生物胺对突触和行为的影响

基本信息

  • 批准号:
    RGPIN-2016-04294
  • 负责人:
  • 金额:
    $ 2.99万
  • 依托单位:
  • 依托单位国家:
    加拿大
  • 项目类别:
    Discovery Grants Program - Individual
  • 财政年份:
    2020
  • 资助国家:
    加拿大
  • 起止时间:
    2020-01-01 至 2021-12-31
  • 项目状态:
    已结题

项目摘要

Nerve cells communicate with each other by releasing chemical signals that alter electrical activity in their target cells. Most of these chemical signals are “peptides” (short chains of amino acids), and some are “biogenic amines”, smaller compounds derived from amino acids. The human brain contains over 100 different peptides, and much about their functions is still not understood. My lab examines how these signaling molecules function and how they give rise to behaviour. We use crayfish and fruit flies as model experimental systems because they contain fewer nerve cells than humans and most other animals, and many of the nerve cells can be identified easily from one specimen to another. The fruit fly genome is fully sequenced, providing an array of “molecular tools” that allow us to determine how specific genes and proteins allow peptides and biogenic amines to alter the activity of nerve and muscle cells. Crayfish have the advantage of larger size, providing more material for biochemical analysis. We use these two model systems to determine the mechanisms through which specific signaling molecules alter the electrical properties of neurons, contraction of muscles and, ultimately, behaviour. During the next five years we will focus mainly on two peptides (proctolin and DPKQDFMRFamide) that are found in fruit flies. Both peptides are neurohormones that induce contraction in muscles and increase the strength of contraction when the muscles are activated by the nerve cells supplying them (motor neurons). We will identify the chemical signaling pathways inside the muscle cells that underlie the effects of these peptides on contraction. In addition to its role as a neurohormone, one of these peptides (proctolin) is released directly onto muscle cells by motor neurons. We will study the consequences of this dual-role of proctolin and determine whether its release from nerve terminals can affect its ction as a circulating hormone. We will also examine the role of proctolin in crawling and turning behaviours exhibited by fruit fly larvae (maggots). We will determine whether proctolin acts within the central nervous system, on muscles or at both sites, and we will identify the cells on which proctolin acts. These studies will increase our understanding of how neuropeptides act on cells and, ultimately, how their actions affect behaviour. This work is important for understanding the fundamental mechanisms underlying behaviour. It is also important to understand how neuropeptides function because they are involved in several diseases.
神经细胞通过释放化学信号来改变目标细胞的电活动,从而相互交流。这些化学信号中的大多数是“肽”(氨基酸的短链),有些是“生物胺”,从氨基酸衍生的较小化合物。人类大脑中含有超过100种不同的肽,关于它们的功能仍然不清楚。我的实验室研究这些信号分子如何发挥作用以及它们如何引起行为。我们使用小龙虾和果蝇作为模型实验系统,因为它们含有的神经细胞比人类和大多数其他动物少,而且许多神经细胞可以很容易地从一个标本到另一个标本中识别出来。果蝇基因组完全测序,提供了一系列“分子工具”,使我们能够确定特定的基因和蛋白质如何允许肽和生物胺改变神经和肌肉细胞的活性。小龙虾具有体积较大的优势,为生化分析提供了更多的材料。我们使用这两个模型系统来确定特定信号分子改变神经元电特性、肌肉收缩以及最终行为的机制。 在接下来的五年里,我们将主要关注果蝇中发现的两种肽(proctolin和DPKQDFMRFamide)。这两种肽都是神经激素,当肌肉被供应它们的神经细胞(运动神经元)激活时,它们诱导肌肉收缩并增加收缩的强度。我们将确定肌肉细胞内的化学信号通路,这些通路是这些肽对收缩作用的基础。除了作为神经激素的作用,这些肽之一(proctolin)被运动神经元直接释放到肌肉细胞上。我们将研究这种双重作用的后果proctolin,并确定其从神经末梢的释放是否会影响其作为循环激素。我们还将研究proctolin在果蝇幼虫(蛆)的爬行和转向行为中的作用。我们将确定proctolin是否作用于中枢神经系统,肌肉或两个网站,我们将确定proctolin作用的细胞。这些研究将增加我们对神经肽如何作用于细胞的理解,并最终了解它们的作用如何影响行为。这项工作对于理解行为背后的基本机制非常重要。了解神经肽的功能也很重要,因为它们与多种疾病有关。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Mercier, Joffre其他文献

Mercier, Joffre的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Mercier, Joffre', 18)}}的其他基金

Effects of invertebrate neuropeptides and biogenic amines on synapses and behavior
无脊椎动物神经肽和生物胺对突触和行为的影响
  • 批准号:
    RGPIN-2016-04294
  • 财政年份:
    2021
  • 资助金额:
    $ 2.99万
  • 项目类别:
    Discovery Grants Program - Individual
Effects of invertebrate neuropeptides and biogenic amines on synapses and behavior
无脊椎动物神经肽和生物胺对突触和行为的影响
  • 批准号:
    RGPIN-2016-04294
  • 财政年份:
    2019
  • 资助金额:
    $ 2.99万
  • 项目类别:
    Discovery Grants Program - Individual
Effects of invertebrate neuropeptides and biogenic amines on synapses and behavior
无脊椎动物神经肽和生物胺对突触和行为的影响
  • 批准号:
    RGPIN-2016-04294
  • 财政年份:
    2018
  • 资助金额:
    $ 2.99万
  • 项目类别:
    Discovery Grants Program - Individual
Effects of invertebrate neuropeptides and biogenic amines on synapses and behavior
无脊椎动物神经肽和生物胺对突触和行为的影响
  • 批准号:
    RGPIN-2016-04294
  • 财政年份:
    2017
  • 资助金额:
    $ 2.99万
  • 项目类别:
    Discovery Grants Program - Individual
Effects of invertebrate neuropeptides and biogenic amines on synapses and behavior
无脊椎动物神经肽和生物胺对突触和行为的影响
  • 批准号:
    RGPIN-2016-04294
  • 财政年份:
    2016
  • 资助金额:
    $ 2.99万
  • 项目类别:
    Discovery Grants Program - Individual
Neuropeptides, synaptic modulation and behavior in arthropods
节肢动物的神经肽、突触调节和行为
  • 批准号:
    46292-2008
  • 财政年份:
    2015
  • 资助金额:
    $ 2.99万
  • 项目类别:
    Discovery Grants Program - Individual
Neuropeptides, synaptic modulation and behavior in arthropods
节肢动物的神经肽、突触调节和行为
  • 批准号:
    46292-2008
  • 财政年份:
    2014
  • 资助金额:
    $ 2.99万
  • 项目类别:
    Discovery Grants Program - Individual
Neuropeptides, synaptic modulation and behavior in arthropods
节肢动物的神经肽、突触调节和行为
  • 批准号:
    46292-2008
  • 财政年份:
    2013
  • 资助金额:
    $ 2.99万
  • 项目类别:
    Discovery Grants Program - Individual
Neuropeptides, synaptic modulation and behavior in arthropods
节肢动物的神经肽、突触调节和行为
  • 批准号:
    46292-2008
  • 财政年份:
    2012
  • 资助金额:
    $ 2.99万
  • 项目类别:
    Discovery Grants Program - Individual
Neuropeptides, synaptic modulation and behavior in arthropods
节肢动物的神经肽、突触调节和行为
  • 批准号:
    46292-2008
  • 财政年份:
    2011
  • 资助金额:
    $ 2.99万
  • 项目类别:
    Discovery Grants Program - Individual

相似国自然基金

海产经济无脊椎动物防卫素的研究
  • 批准号:
    40086001
  • 批准年份:
    2000
  • 资助金额:
    21.0 万元
  • 项目类别:
    专项基金项目

相似海外基金

Effects of invertebrate neuropeptides and biogenic amines on synapses and behavior
无脊椎动物神经肽和生物胺对突触和行为的影响
  • 批准号:
    RGPIN-2016-04294
  • 财政年份:
    2021
  • 资助金额:
    $ 2.99万
  • 项目类别:
    Discovery Grants Program - Individual
Effects of invertebrate neuropeptides and biogenic amines on synapses and behavior
无脊椎动物神经肽和生物胺对突触和行为的影响
  • 批准号:
    RGPIN-2016-04294
  • 财政年份:
    2019
  • 资助金额:
    $ 2.99万
  • 项目类别:
    Discovery Grants Program - Individual
Effects of invertebrate neuropeptides and biogenic amines on synapses and behavior
无脊椎动物神经肽和生物胺对突触和行为的影响
  • 批准号:
    RGPIN-2016-04294
  • 财政年份:
    2018
  • 资助金额:
    $ 2.99万
  • 项目类别:
    Discovery Grants Program - Individual
Effects of invertebrate neuropeptides and biogenic amines on synapses and behavior
无脊椎动物神经肽和生物胺对突触和行为的影响
  • 批准号:
    RGPIN-2016-04294
  • 财政年份:
    2017
  • 资助金额:
    $ 2.99万
  • 项目类别:
    Discovery Grants Program - Individual
Effects of invertebrate neuropeptides and biogenic amines on synapses and behavior
无脊椎动物神经肽和生物胺对突触和行为的影响
  • 批准号:
    RGPIN-2016-04294
  • 财政年份:
    2016
  • 资助金额:
    $ 2.99万
  • 项目类别:
    Discovery Grants Program - Individual
Invertebrate neuropeptides: physiological roles & mechanisms of action
无脊椎动物神经肽:生理作用
  • 批准号:
    46292-2003
  • 财政年份:
    2007
  • 资助金额:
    $ 2.99万
  • 项目类别:
    Discovery Grants Program - Individual
Invertebrate neuropeptides and their receptors: regulators of metamorphosis, reproducctin and muscle contraction
无脊椎动物神经肽及其受体:变态、生殖和肌肉收缩的调节剂
  • 批准号:
    36481-2005
  • 财政年份:
    2007
  • 资助金额:
    $ 2.99万
  • 项目类别:
    Discovery Grants Program - Individual
Mass Spectrometric Studies of Neuropeptides in Feeding
喂养中神经肽的质谱研究
  • 批准号:
    7098645
  • 财政年份:
    2006
  • 资助金额:
    $ 2.99万
  • 项目类别:
Invertebrate neuropeptides: physiological roles & mechanisms of action
无脊椎动物神经肽:生理作用
  • 批准号:
    46292-2003
  • 财政年份:
    2006
  • 资助金额:
    $ 2.99万
  • 项目类别:
    Discovery Grants Program - Individual
Invertebrate neuropeptides and their receptors: regulators of metamorphosis, reproducctin and muscle contraction
无脊椎动物神经肽及其受体:变态、生殖和肌肉收缩的调节因子
  • 批准号:
    36481-2005
  • 财政年份:
    2006
  • 资助金额:
    $ 2.99万
  • 项目类别:
    Discovery Grants Program - Individual
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了