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Development of innovative therapeutic strategies in cystic fibrosis for improvement of CFTR-targeted treatments and restoration of airway epithelial integrity in infected lungs from patients harboring various mutations

Development of innovative therapeutic strategies in cystic fibrosis for improvement of CFTR-targeted treatments and restoration of airway epithelial integrity in infected lungs from patients harboring various mutations
开发囊性纤维化的创新治疗策略，以改善 CFTR 靶向治疗并恢复携带各种突变的患者感染肺部的气道上皮完整性
批准号：
443897
负责人：
Brochiero Emmanuelle
金额：
$61.02万
依托单位：
Centre hospitalier de l'Universit de Montral (CHUM)
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2021
资助国家：
加拿大
项目状态：
未结题
起止时间：
2021-04-01 至 2026-04-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=443897&lang=en
关键词：
Airway Epithelial Repair Bacterial Infections Cftr Cftr Modulators Cystic Fibrosis K+ Channels Lung Damage Patient-Derived Primary Cells And Living Tissues Respiratory Health Therapeutic Strategies

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中文摘要
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英文摘要
Cystic fibrosis (CF), the most common fatal genetic disease in Canada, is due to mutations in the gene coding for a protein called CFTR. Although CF affects many organs, the progressive lung damage due to bacterial infections remains the first cause of mo
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