Regulation of tau phosphorylation and splicing during post-embryonic development

胚胎后发育过程中 tau 蛋白磷酸化和剪接的调控

• 批准号: RGPIN-2016-05862
• 负责人: Planel, Emmanuel
• 金额: $ 2.4万
• 依托单位: Université Laval
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=709896
• 关键词: Regulation; tau; phosphorylation; splicing; during

Tau is a protein that helps maintain the skeleton of the neurons in good working order. It does that by binding and straightening the scaffolds that constitute the backbone of the neuronal extensions called axons. This ability is regulated by changes in tau protein internal structure and external surface. Both changes are regulated during development and have an impact in adulthood. We have made the exciting discovery that temperature is a powerful regulator of tau during post-embryonic development and we expect that it has an impact in adulthood. The purpose of this proposal is therefore to examine the mechanisms, and the functional and behavioral consequences underlying the regulation of tau by temperature.

Tau是一种蛋白质，有助于维持神经元的骨架处于良好的工作状态。它通过结合和拉直支架来实现这一点，这些支架构成了称为轴突的神经元延伸的骨干。这种能力受tau蛋白内部结构和外表面变化的调节。这两种变化在发育过程中受到调节，并在成年期产生影响。我们已经取得了令人兴奋的发现，温度是胚胎后发育期间tau蛋白的强大调节因子，我们预计它会对成年期产生影响。因此，本提案的目的是研究温度调节tau的机制以及功能和行为后果。