Role of serine/threonine phosphatases in tau protein regulation in vivo

丝氨酸/苏氨酸磷酸酶在体内 tau 蛋白调节中的作用

• 批准号: 386336-2010
• 负责人: Planel, Emmanuel
• 金额: $ 2.33万
• 依托单位: Université Laval
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2012
• 资助国家: 加拿大
• 起止时间: 2012-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=505949
• 关键词: Role; serine; threonine; phosphatases; tau

Tau is a microtubule-associated protein that is abundant in the brain and expressed mainly in axons. Its function is to binding and strengthen the microtubules that constitute the supporting scaffold of the axon. During development tau has more phosphates attached and its composition is different than in the adult brain. To understand the regulation of tau by phosphatases, enzymes that removes phosphates from proteins, we will use two mouse models in which PP1 and PP2A -two main tau phosphatases- are inhibited. We hope that this work will demonstrate that both are implicated in the differential regulation of tau during development.

Tau是一种微管相关蛋白，在大脑中含量丰富，主要在轴突中表达。它的功能是结合和加强构成轴突支撑支架的微管。在发育过程中，tau附着了更多的磷酸盐，其组成与成人大脑中的不同。为了了解磷酸酶对tau的调节，我们将使用两个小鼠模型，其中两个主要的tau磷酸酶PP1和PP2A被抑制。我们希望这项工作将证明两者都参与了tau在发育过程中的不同调控。