Environmental and hormonal control of seed development and germination
种子发育和发芽的环境和激素控制
基本信息
- 批准号:RGPIN-2017-05980
- 负责人:
- 金额:$ 2.91万
- 依托单位:
- 依托单位国家:加拿大
- 项目类别:Discovery Grants Program - Individual
- 财政年份:2020
- 资助国家:加拿大
- 起止时间:2020-01-01 至 2021-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Plants face a multitude of biotic and abiotic stresses due to their sessile nature and have evolved various strategies through which they can effectively balance growth and defense against stressors. A strategy employed by plants is to maintain an appropriate hormone balance at any given moment. Plant hormones are small molecules whose signaling pathways interact, together forming a complex crosstalk network that regulates the plant's response to environmental stressors. The hormone abscisic acid (ABA) is critical for initiating a stress response within the plant, inhibiting growth and promoting survival under various stresses. Regardless of the type of stress that plants are exposed to, the result is energy deprivation that activates energy sensors to maintain energy homeostasis. SnRK1 (Sucrose non-fermenting Related Kinase1) is the plant ortholog of yeast Snf1 and mammalian AMPK energy sensors. Notably, AMPK is a metabolic tumour suppressor, currently a target for cancer and diabetes treatment and prevention. SnRK1 activation induces large transcriptional reprogramming under metabolic stress to conserve energy. Despite the pivotal role of these essential kinase complexes in energy homeostasis, few targets are known. SnRK1 and ABA signaling pathways intersect during stress responses to promote survival, however, the mechanism of this interaction is unclear.
Seeds constitute up to 70% of our food intake, as direct consumption and animal feed. The proposed research program aims to understand how hormones regulate plant responses to environmental cues, with a focus on seed development and early vegetative growth. A combination of molecular genetics and targeted systems biology approaches will be used to: a) study the mechanism of hormone crosstalk during seed development and germination under abiotic stresses; b) understand the mechanisms of interaction between the SnRK1 and ABA signaling pathways, both of which are activated during stress; c) identify novel regulators of seed development and germination under abiotic stresses. In the long term, we aim to understand how plants integrate endogenous signals and external cues to adapt to changing environments. Scarcity of fresh water and increasing temperature due to global climate change are major threats to food security. Plants ability to respond to environmental stressors is critical during reproductive development, at which time water and heat stresses, especially when combined, can severely reduce seed filling and cause great yield losses. This is a great concern in Canada, where increasing temperature and drought have negatively impacted the yield of important agricultural crops, such as wheat, canola and corn in the past years. The knowledge gained from this program will aid in the future selection of plants with enhanced stress tolerance during seed development, greatly improving the yield of important agricultural crops.
植物由于其固着的性质,面临着大量的生物和非生物胁迫,并进化出各种策略,通过这些策略,它们可以有效地平衡生长和防御逆境。植物采用的一种策略是在任何给定时刻保持适当的激素平衡。植物激素是一种小分子,它们的信号通路相互作用,共同形成一个复杂的串扰网络,调节植物对环境胁迫的反应。激素脱落酸(ABA)在植物体内启动逆境反应、抑制生长和促进在各种逆境下的存活是至关重要的。不管植物面临的是哪种类型的压力,其结果都是能量匮乏,从而激活能量传感器来维持能量动态平衡。SnRK1是酵母Snf1和哺乳动物AMPK能量感受器的植物同源基因。值得注意的是,AMPK是一种新陈代谢肿瘤抑制药,目前是癌症和糖尿病治疗和预防的靶点。SnRK1激活诱导代谢应激下的大规模转录重编程以保存能量。尽管这些必需的激酶复合体在能量平衡中起着关键作用,但很少有人知道它的靶点。SnRK1和ABA信号通路在应激反应中相交以促进生存,但这种相互作用的机制尚不清楚。
种子占我们食物摄入量的70%,作为直接消费和动物饲料。这项拟议的研究计划旨在了解激素如何调节植物对环境线索的反应,重点是种子发育和早期营养生长。分子遗传学和靶向系统生物学相结合的方法将被用于:a)研究非生物胁迫下种子发育和萌发过程中激素串扰的机制;b)了解SnRK1和ABA信号通路之间相互作用的机制,这两个信号通路在胁迫期间都被激活;c)寻找非生物胁迫下种子发育和萌发的新调节因子。从长远来看,我们的目标是了解植物如何整合内源信号和外部信号,以适应不断变化的环境。全球气候变化导致的淡水短缺和气温上升是粮食安全的主要威胁。植物对环境胁迫的反应能力在生殖发育过程中至关重要,在生殖发育过程中,水和热胁迫,特别是当水和热胁迫结合在一起时,会严重减少种子灌浆,造成巨大的产量损失。这在加拿大是一个非常令人担忧的问题,在过去几年里,气温上升和干旱对小麦、油菜籽和玉米等重要农作物的产量产生了负面影响。从该计划中获得的知识将有助于未来在种子发育过程中选择耐逆性增强的植物,大大提高重要农作物的产量。
项目成果
期刊论文数量(0)
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Gazzarrini, Sonia其他文献
Inhibition of FUSCA3 degradation at high temperature is dependent on ABA signaling and is regulated by the ABA/GA ratio
- DOI:
10.1080/15592324.2016.1247137 - 发表时间:
2016-01-01 - 期刊:
- 影响因子:2.9
- 作者:
Chiu, Rex Shun;Saleh, Yazan;Gazzarrini, Sonia - 通讯作者:
Gazzarrini, Sonia
The C-terminal domain of FUSCA3 negatively regulates mRNA and protein levels, and mediates sensitivity to the hormones abscisic acid and gibberellic acid in Arabidopsis
- DOI:
10.1111/j.1365-313x.2010.04307.x - 发表时间:
2010-10-01 - 期刊:
- 影响因子:7.2
- 作者:
Lu, Qing Shi;dela Paz, Joelle;Gazzarrini, Sonia - 通讯作者:
Gazzarrini, Sonia
ABA-dependent inhibition of the ubiquitin proteasome system during germination at high temperature in Arabidopsis
- DOI:
10.1111/tpj.13293 - 发表时间:
2016-12-01 - 期刊:
- 影响因子:7.2
- 作者:
Chiu, Rex Shun;Pan, Shiyue;Gazzarrini, Sonia - 通讯作者:
Gazzarrini, Sonia
An abscisic acid-responsive protein interaction network for sucrose non-fermenting related kinase1 in abiotic stress response
- DOI:
10.1038/s42003-020-0866-8 - 发表时间:
2020-03-26 - 期刊:
- 影响因子:5.9
- 作者:
Carianopol, Carina Steliana;Chan, Aaron Lorheed;Gazzarrini, Sonia - 通讯作者:
Gazzarrini, Sonia
Spatiotemporal Restriction of FUSCA3 Expression by Class I BPCs Promotes Ovule Development and Coordinates Embryo and Endosperm Growth
- DOI:
10.1105/tpc.19.00764 - 发表时间:
2020-06-01 - 期刊:
- 影响因子:11.6
- 作者:
Wu, Jian;Mohamed, Deka;Gazzarrini, Sonia - 通讯作者:
Gazzarrini, Sonia
Gazzarrini, Sonia的其他文献
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{{ truncateString('Gazzarrini, Sonia', 18)}}的其他基金
Environmental and hormonal control of seed development and germination
种子发育和发芽的环境和激素控制
- 批准号:
RGPIN-2017-05980 - 财政年份:2022
- 资助金额:
$ 2.91万 - 项目类别:
Discovery Grants Program - Individual
Environmental and hormonal control of seed development and germination
种子发育和发芽的环境和激素控制
- 批准号:
RGPIN-2017-05980 - 财政年份:2021
- 资助金额:
$ 2.91万 - 项目类别:
Discovery Grants Program - Individual
Environmental and hormonal control of seed development and germination
种子发育和发芽的环境和激素控制
- 批准号:
RGPIN-2017-05980 - 财政年份:2019
- 资助金额:
$ 2.91万 - 项目类别:
Discovery Grants Program - Individual
Environmental and hormonal control of seed development and germination
种子发育和发芽的环境和激素控制
- 批准号:
RGPIN-2017-05980 - 财政年份:2018
- 资助金额:
$ 2.91万 - 项目类别:
Discovery Grants Program - Individual
Environmental and hormonal control of seed development and germination
种子发育和发芽的环境和激素控制
- 批准号:
RGPIN-2017-05980 - 财政年份:2017
- 资助金额:
$ 2.91万 - 项目类别:
Discovery Grants Program - Individual
Regulatory Networks during Developmental Phase Transitions and Abiotic Stresses
发育阶段转变和非生物胁迫期间的调控网络
- 批准号:
327232-2012 - 财政年份:2015
- 资助金额:
$ 2.91万 - 项目类别:
Discovery Grants Program - Individual
Regulatory Networks during Developmental Phase Transitions and Abiotic Stresses
发育阶段转变和非生物胁迫期间的调控网络
- 批准号:
327232-2012 - 财政年份:2014
- 资助金额:
$ 2.91万 - 项目类别:
Discovery Grants Program - Individual
Regulatory Networks during Developmental Phase Transitions and Abiotic Stresses
发育阶段转变和非生物胁迫期间的调控网络
- 批准号:
327232-2012 - 财政年份:2013
- 资助金额:
$ 2.91万 - 项目类别:
Discovery Grants Program - Individual
Regulatory Networks during Developmental Phase Transitions and Abiotic Stresses
发育阶段转变和非生物胁迫期间的调控网络
- 批准号:
327232-2012 - 财政年份:2012
- 资助金额:
$ 2.91万 - 项目类别:
Discovery Grants Program - Individual
Developmental phase transitions in plants
植物的发育阶段转变
- 批准号:
327232-2006 - 财政年份:2011
- 资助金额:
$ 2.91万 - 项目类别:
Discovery Grants Program - Individual
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Environmental and hormonal control of seed development and germination
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