High-throughput Biocatalyst Manufacturing for Environmental Biotechnology

用于环境生物技术的高通量生物催化剂制造

• 批准号: 10082322
• 负责人: Fatemeh Shirazi
• 金额: $ 30万
• 依托单位: MICROVI BIOTECH, INC.
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-08-11 至 2022-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10082322
• 关键词: Address; Aromatic Polycyclic Hydrocarbons; Australia; Biological; Bioremediations; Biotechnology; California; Categories; Chemicals; Defect; Detection; Development; Disadvantaged; Disease; Disinfection; Engineering; Ensure; Environment; Environmental Engineering technology; Equilibrium; Excision; Funding; Grant; Heart; Hormonal; Household; Hydrocarbons; Immune System Diseases; In Situ; Kidney Diseases; Lead; Life Cycle Stages; Link; Liquid substance; Liver diseases; Maintenance; Malignant Neoplasms; Manufacturer Name; Measures; Mission; Modeling; Municipalities; National Institute of Environmental Health Sciences; Nitrates; Organic Chemicals; Outcome; Perchlorates; Performance; Pesticides; Phase; Polychlorinated Biphenyls; Positioning Attribute; Privatization; Process; Production; Public Health; Quality Control; Recording of previous events; Recovery; Recycling; Research; Resources; Risk; Running; Rural Community; Safety; Site; Small Business Innovation Research Grant; Small Business Technology Transfer Research; Solvents; Stream; System; Technology; United States; United States National Institutes of Health; Water; Water Pollutants; Water Supply; Work; Xenobiotics; base; commercialization; contaminated water; conventional therapy; cost; design; disability; drinking water; engineering design; experience; flexibility; ground water; high throughput technology; improved; innovation; manufacturing process; nervous system disorder; new technology; next generation; oxidation; pollutant; prevent; programs; remediation; reproductive; scale up; success; superfund site; wasting; water treatment

Project Summary / Abstract A variety of hazardous compounds continue to pose serious and widespread risks to public health and safety in the United States. Organic compounds, in particular, such as chlorinated solvents, hydrocarbons, disinfection byproducts, pesticides, polyaromatic hydrocarbons (PAHs), polychlorinated biphenyls (PCBs), and other xenobiotic (not naturally occurring) organic chemicals comprise a major category of water contaminants. These high-priority pollutants are often regulated by state and federal agencies due to their proven links to cancer and various diseases, including liver or kidney disease, immune dysfunction, nervous system disorders, and hormonal or reproductive defects. However, existing chemical, physical and biological technologies to remove these compounds suffer from significant limitations that lead to low treatment efficiency and/or increases costs for Superfund site managers, municipalities and water supplies. This project is based on a prior Phase II project involving the successful development of an enhanced cometabolism-based biological technology that significantly overcomes the limitations of conventional treatment systems. This new technology has been demonstrated to degrades the hazardous organic compounds into harmless byproducts instead of producing a concentrated secondary waste stream. Moreover, this new technology offers significant reductions in energy and maintenance costs compared with chemical or UV oxidation, and offers both an in-situ and ex-situ treatment options across a range of operating conditions to simultaneously and cost-effectively remove hazardous organic compounds from water. In this proposal, the manufacturing processes underlying this technology are significantly improved in terms of manufacturing throughput, waste reduction, quality control and environmental footprint. Specifically, the existing production process for the technology is redesigned and re-engineered using semi-automated, high-throughput process units to optimize material usage, reduce labor costs, ensure liquid and chemical recycling and ultimately lead to a significant reduction in manufacturing costs, thereby enhancing the widespread implementation and availability of the treatment technology to a greater number of sites, especially disadvantaged and rural communities which often lack the resources to address local water contaminations. The outcome of this project is a significant advance in the versatile manufacturing of biocatalyst composites at the heart of the treatment of hundreds of contaminants. The successful result of this project holds significant promise in addressing harmful contaminants that are not effectively treatable using existing technologies, and thereby recovering substantial stakeholder value for public and private stewardship of water resources.

项目总结/摘要 各种危险化合物继续对公共健康和安全构成严重和广泛的风险， 美国的有机化合物，特别是氯化溶剂、碳氢化合物、消毒剂等 副产品，农药，多环芳烃（PAH），多氯联苯（PCB），和其他 异生物质（非天然存在的）有机化学品构成水污染物的主要类别。这些 高优先级污染物通常由州和联邦机构管理，因为它们与癌症的联系已被证实， 各种疾病，包括肝脏或肾脏疾病、免疫功能障碍、神经系统疾病，以及 荷尔蒙或生殖缺陷。然而，现有的化学、物理和生物技术， 这些化合物受到显著的限制，导致低处理效率和/或增加成本 为超级基金现场管理人员、市政当局和供水部门提供服务。 该项目是基于先前的第二阶段项目，该项目涉及成功开发一个增强的 基于共代谢的生物技术，显著克服了传统治疗的局限性 系统.这项新技术已被证明可以将有害的有机化合物降解为 无害的副产品，而不是产生浓缩的二次废物流。此外，这一新 与化学品或紫外线相比， 氧化，并在一系列操作条件下提供原位和非原位处理选项， 同时且成本有效地从水中去除有害有机化合物。 在该提案中，该技术的制造工艺在以下方面得到了显著改善： 生产能力、减少废物、质量控制和环境足迹。具体而言，现有 该技术的生产过程被重新设计和重新设计，使用半自动化，高通量 工艺单元优化材料使用，降低劳动力成本，确保液体和化学品回收， 导致制造成本的显著降低，从而增强了广泛的实施， 向更多地点提供处理技术，特别是处境不利和农村地区 这些社区往往缺乏解决当地水污染问题的资源。 该项目的成果是在生物催化剂复合材料的多功能制造方面取得的重大进展， 数百种污染物处理的核心。该项目的成功具有重要意义 在解决使用现有技术无法有效处理的有害污染物方面的承诺，以及 从而为公共和私营部门管理水资源恢复了利益攸关方的实质性价值。