Leveraging large-scale sequencing to identify and validate genetic influences of movement disorders.

利用大规模测序来识别和验证运动障碍的遗传影响。

• 批准号: 453910
• 负责人: Dilliott Allison A
• 金额: $ 10.2万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Fellowship Programs
• 财政年份: 2021
• 资助国家: 加拿大
• 起止时间: 2021-09-01 至 2023-09-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=453910&lang=en
• 关键词: Amyotrophic Lateral Sclerosis; Bioinformatics; Essential Tremor; Functional Gene Sets; Gene Burden Analysis; Genetics; Movement Disorders; Neurodegenerative Disease; Next-Generation Sequencing; Rare Variant Enrichment

Movement disorders are a subcategory of neurodegenerative diseases caused by progressive deterioration of brain cells and resulting in muscle weakness, abnormal movements, and/or tremors. The disorders may be rarer, but fatal, such as amyotrophic lateral

运动障碍是由脑细胞的进行性退化引起的神经退行性疾病的亚类，并导致肌肉无力、异常运动和/或震颤。这些疾病可能比较罕见，但致命，如肌萎缩侧索硬化症。