Human limbic system: Bridging micro- and macroscopic anatomy using advanced imaging

人体边缘系统：利用先进成像连接微观和宏观解剖学

• 批准号: RGPIN-2018-06278
• 负责人: LadbonBernasconi, Neda
• 金额: $ 3.42万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=713627
• 关键词: Human; limbic; system; Bridging; micro

The limbic system has long been recognized to play a key role in how we experience and control emotions. While one of the most widely studied regions has been the amygdala, frequently implicated in emotional reactivity and recognition, anterior cingulate, orbitofrontal, and ventrolateral prefrontal have been shown to play an important role in emotion reappraisal. Moreover, recent findings from task-based as well as task-free fMRI have shown that multiple emotion generating and regulating regions interact in complex ways that ultimately result in subjective emotional experiences and behaviors, suggesting that it is not sufficient to consider these areas and their underlying processes in isolation. In humans, a detailed in vivo parcellation of the limbic system that integrates structural markup, function and network-level organization is lacking. The overall goal of this research for the next 5 years is generate a comprehensive in vivo cartography of the human limbic system through the development of a framework bridging information from microscale cytoarchitecture (derived from 3D post-mortem histology), mesoscale tissue properties (obtained from in vivo submillimetric quantitative contrasts), and macroscale connectivity (inferred from in vivo diffusion MRI and resting-state fMRI), tested and validated within a unique multidisciplinary research and training environment. Multivariate statistical modeling will integrate different levels of analysis. Mediation models will link microstructure, function, and differences in emotion regulation capacity. A main goal is to map the limbic system in the individual's anatomical space without the need for across subject averaging, a necessary step to advance the understanding of the physiology of this network. This program will provide excellent training opportunities for the next generation of scientists and advance our understanding of anatomo-functional organization of this circuitry pivotal for affect, relationships and well-being in day-to-day life. Ultimately, this program may foster the development of emotion regulation strategies to cope with everyday problems.

长期以来，该边缘系统在我们体验和控制情绪方面发挥着关键作用。 虽然研究最广泛的区域之一是杏仁核，经常与情绪反应性和识别有关，前扣带回，眶额和腹侧前额叶在情绪重新评估中起着重要作用。此外，来自基于任务的FMRI的最新发现表明，产生和调节区域的多种情感以复杂的方式相互作用，最终导致主观的情感体验和行为，这表明不足以考虑这些领域及其基本过程。在人类中，缺乏整合结构标记，功能和网络级组织的边缘系统的详细体内分析。 The overall goal of this research for the next 5 years is generate a comprehensive in vivo cartography of the human limbic system through the development of a framework bridging information from microscale cytoarchitecture (derived from 3D post-mortem histology), mesoscale tissue properties (obtained from in vivo submillimetric quantitative contrasts), and macroscale connectivity (inferred from in vivo diffusion MRI and resting-state fMRI），在独特的多学科研究和培训环境中进行了测试和验证。多元统计建模将整合不同级别的分析。调解模型将链接情绪调节能力的微结构，功能和差异。一个主要目标是在个人的解剖空间中绘制边缘系统，而无需跨主题平均，这是提高对该网络生理学理解的必要步骤。 该计划将为下一代科学家提供极好的培训机会，并促进我们对该电路关键的Anatomo功能组织的理解，以实现日常生活中的情感，人际关系和福祉。最终，该计划可能会促进情绪调节策略的发展，以应对日常问题。