Human limbic system: Bridging micro- and macroscopic anatomy using advanced imaging

人体边缘系统：利用先进成像连接微观和宏观解剖学

• 批准号: RGPIN-2018-06278
• 负责人: LadbonBernasconi, Neda
• 金额: $ 3.42万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=713627
• 关键词: Human; limbic; system; Bridging; micro

The limbic system has long been recognized to play a key role in how we experience and control emotions. While one of the most widely studied regions has been the amygdala, frequently implicated in emotional reactivity and recognition, anterior cingulate, orbitofrontal, and ventrolateral prefrontal have been shown to play an important role in emotion reappraisal. Moreover, recent findings from task-based as well as task-free fMRI have shown that multiple emotion generating and regulating regions interact in complex ways that ultimately result in subjective emotional experiences and behaviors, suggesting that it is not sufficient to consider these areas and their underlying processes in isolation. In humans, a detailed in vivo parcellation of the limbic system that integrates structural markup, function and network-level organization is lacking. The overall goal of this research for the next 5 years is generate a comprehensive in vivo cartography of the human limbic system through the development of a framework bridging information from microscale cytoarchitecture (derived from 3D post-mortem histology), mesoscale tissue properties (obtained from in vivo submillimetric quantitative contrasts), and macroscale connectivity (inferred from in vivo diffusion MRI and resting-state fMRI), tested and validated within a unique multidisciplinary research and training environment. Multivariate statistical modeling will integrate different levels of analysis. Mediation models will link microstructure, function, and differences in emotion regulation capacity. A main goal is to map the limbic system in the individual's anatomical space without the need for across subject averaging, a necessary step to advance the understanding of the physiology of this network. This program will provide excellent training opportunities for the next generation of scientists and advance our understanding of anatomo-functional organization of this circuitry pivotal for affect, relationships and well-being in day-to-day life. Ultimately, this program may foster the development of emotion regulation strategies to cope with everyday problems.

边缘系统长期以来一直被认为在我们如何体验和控制情绪方面发挥着关键作用。 虽然杏仁核是研究最广泛的区域之一，经常与情绪反应和识别有关，但前扣带、眶额和腹外侧前额叶已被证明在情绪重新评价中发挥重要作用。此外，基于任务和无任务的fMRI的最新研究结果表明，多个情绪产生和调节区域以复杂的方式相互作用，最终导致主观的情绪体验和行为，这表明孤立地考虑这些区域及其潜在过程是不够的。在人类中，缺乏一个详细的边缘系统，整合结构标记，功能和网络级组织的体内包裹。 本研究未来5年的总体目标是通过开发一个框架，将来自微尺度细胞结构的信息桥接起来，生成一个全面的人类边缘系统体内制图（源自3D死后组织学），中尺度组织特性（从体内亚毫米定量对比获得）和宏观尺度连接（从体内扩散MRI和静息态fMRI推断），在独特的多学科研究和培训环境中进行测试和验证。多元统计建模将整合不同层次的分析。调解模型将联系微观结构，功能和情绪调节能力的差异。一个主要的目标是映射边缘系统在个人的解剖空间，而不需要跨学科平均，一个必要的步骤，以促进对这个网络的生理学的理解。 该计划将为下一代科学家提供良好的培训机会，并促进我们对这一电路的解剖功能组织的理解，这对日常生活中的影响，关系和福祉至关重要。最终，这个项目可能会促进情绪调节策略的发展，以科普日常问题。