Human limbic system: Bridging micro- and macroscopic anatomy using advanced imaging

人体边缘系统：利用先进成像连接微观和宏观解剖学

• 批准号: RGPIN-2018-06278
• 负责人: LadbonBernasconi, Neda
• 金额: $ 3.42万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=713627
• 关键词: Human; limbic; system; Bridging; micro

The limbic system has long been recognized to play a key role in how we experience and control emotions. While one of the most widely studied regions has been the amygdala, frequently implicated in emotional reactivity and recognition, anterior cingulate, orbitofrontal, and ventrolateral prefrontal have been shown to play an important role in emotion reappraisal. Moreover, recent findings from task-based as well as task-free fMRI have shown that multiple emotion generating and regulating regions interact in complex ways that ultimately result in subjective emotional experiences and behaviors, suggesting that it is not sufficient to consider these areas and their underlying processes in isolation. In humans, a detailed in vivo parcellation of the limbic system that integrates structural markup, function and network-level organization is lacking. The overall goal of this research for the next 5 years is generate a comprehensive in vivo cartography of the human limbic system through the development of a framework bridging information from microscale cytoarchitecture (derived from 3D post-mortem histology), mesoscale tissue properties (obtained from in vivo submillimetric quantitative contrasts), and macroscale connectivity (inferred from in vivo diffusion MRI and resting-state fMRI), tested and validated within a unique multidisciplinary research and training environment. Multivariate statistical modeling will integrate different levels of analysis. Mediation models will link microstructure, function, and differences in emotion regulation capacity. A main goal is to map the limbic system in the individual's anatomical space without the need for across subject averaging, a necessary step to advance the understanding of the physiology of this network. This program will provide excellent training opportunities for the next generation of scientists and advance our understanding of anatomo-functional organization of this circuitry pivotal for affect, relationships and well-being in day-to-day life. Ultimately, this program may foster the development of emotion regulation strategies to cope with everyday problems.

长期以来，边缘系统一直被认为在我们体验和控制情绪的方式中发挥着关键作用。杏仁核是研究最广泛的区域之一，经常与情绪反应和识别有关，而前扣带回、眶前额叶和前额腹外侧区被证明在情绪重新评估中起着重要作用。此外，基于任务和无任务功能磁共振成像的最新研究结果表明，多个情绪产生和调节区域以复杂的方式相互作用，最终导致主观情绪体验和行为，这表明孤立地考虑这些区域及其潜在过程是不够的。在人类中，缺乏整合结构标记、功能和网络级组织的边缘系统的体内详细分离。 这项研究未来5年的总体目标是通过开发一个框架，通过在独特的多学科研究和培训环境中测试和验证来自微观细胞结构(来自3D死后组织学)、中尺度组织属性(从体内亚毫米定量对比获得)和宏观连接(从体内扩散磁共振成像和静息状态功能磁共振成像推断)的信息，生成全面的人体边缘系统在体制图。多元统计建模将整合不同层次的分析。中介模型将微观结构、功能和情绪调节能力的差异联系起来。一个主要的目标是绘制个人解剖空间中的边缘系统图，而不需要跨对象平均，这是推进对这个网络的生理学理解的必要步骤。 这项计划将为下一代科学家提供极好的培训机会，并增进我们对这一回路的解剖功能组织的理解，该回路对日常生活中的情感、关系和福祉至关重要。最终，这个项目可能会促进情绪调节策略的发展，以应对日常问题。