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The function of respiratory-linked local field potential oscillations in human olfactory and limbic brain regions

人类嗅觉和边缘脑区域与呼吸相关的局部场电位振荡的功能

基本信息

批准号：
10391438
负责人：
Christina Maria Zelano
金额：
$ 40.09万
依托单位：
NORTHWESTERN UNIVERSITY AT CHICAGO
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-05-01 至 2023-10-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10391438
关键词：
Air Movements Amygdaloid structure Anatomy Anxiety Anxiety Disorders Area Attention Behavior Brain Brain Stem Brain imaging Brain region Breathing Cause of Death Chemicals Code Communication Data Detection Diagnosis Diffusion Disease Electric Stimulation Electroencephalography Emotions Environment Epilepsy Fostering Foundations Frequencies Functional Magnetic Resonance Imaging Functional disorder Generalized Anxiety Disorder Goals Human Imaging Techniques Inhalation Knowledge Learning Limbic System Link Magnetic Resonance Imaging Measures Medial Mediating Memory Modality Modification Monitor Nature Nose Odors Olfactory Pathways Oral Parkinson Disease Patients Periodicity Phase Psychophysics Research Respiration Respiration Disorders Respiratory Signs and Symptoms Respiratory physiology Rodent Role Sampling Smell Perception Stimulus Structure Structure of terminal stria nuclei of preoptic region Techniques Testing anxious clinical anxiety clinical application experimental study insight nervous system disorder neural network neuroimaging neuromechanism novel olfactory bulb piriform cortex relating to nervous system respiratory response spectrograph sudden unexpected death in epilepsy tractography

项目摘要

Since it is not possible to encounter a smell in our external environment without first inhaling through the nose, stimulus sampling in the olfactory system is inextricably linked to breathing. Respiratory-driven local field potential (LFP) oscillations are important for odor coding mechanisms in the rodent olfactory bulb, but their role in higher olfactory structures such as piriform cortex is not well understood, with even less known about respiratory oscillations in the human brain. While breathing drives oscillations in the brain, the reverse must also be true; stimulus sampling in the olfactory system requires overriding of autonomic respiratory rhythms in order to achieve intentional sniffing and fast adaptive sniff modifications in response to chemical stimuli. The overarching goal of this proposal is to understand the function of respiratory oscillations in the human brain, including their role in the formation of odor-evoked responses in olfactory brain regions and fostering communication across limbic networks involved in odor sampling and fast adaptive sniffing modifications. We also aim to elucidate limbic networks involved in olfactory sampling behaviors. To measure LFPs from medial olfactory structures in the human brain, we will use intracranial electroencephalography (iEEG) with a high sampling rate (up to 10,000Hz), allowing analysis of limbic LFP oscillations across a range of frequencies. We will use a combination of iEEG, direct electrical stimulation, psychophysics and functional neuroimaging and tractography techniques to accomplish the goals of three Specific Aims. First, we will test the hypothesis that slow respiratory-linked LFP oscillations organize the spectral and temporal structure of odor-evoked responses in human piriform cortex. To isolate the impact of slow respiratory-driven oscillations on odor codes, we will deliver odors in the presence and absence of sniffs, accomplished by velopharyngeal closure paired with artificial air flow through the nose. Second, we will test the hypothesis that slow respiratory oscillations across a limbic network of regions important for respiratory control mediate odor sampling, or sniffing behaviors. Here we will use iEEG techniques, electrical stimulation and MRI techniques to study limbic networks involved in the control of nasal breathing with a particular emphasis on the amygdala. Third, we will use iEEG, electrical stimulation and psychophysics to test the hypothesis that adaptive fast sniffing reductions in response to potentially threatening odors are mediated by the amygdala, and can generalize to non-olfactory stimuli in anxious states. The proposed studies have several direct clinical applications. Research on Sudden Unexpected Death in Epilepsy (SUDEP), the most common cause of death in patients with Epilepsy, implicates respiratory dysfunction as a potential cause, with converging evidence for an amygdalar role in the disease (13,14). In so far as our proposal aims to deepen understanding of the neural mechanisms of the amygdala's role in respiratory control, these studies will be important in gaining a better understanding of SUDEP. Our research will also elucidate dysfunctional olfactory-limbic networks underlying clinical anxiety.

因为在我们的外部环境中，如果不先用鼻子吸气，是不可能闻到气味的，

项目成果

期刊论文数量（18）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Ictal central apneas in temporal lobe epilepsies.

DOI：
10.1016/j.yebeh.2020.107434
发表时间：
2020-11
期刊：
Epilepsy & behavior : E&B
影响因子：
0
作者：
Tio E;Culler GW;Bachman EM;Schuele S
通讯作者：
Schuele S

Smell-induced gamma oscillations in human olfactory cortex are required for accurate perception of odor identity.

DOI：
10.1371/journal.pbio.3001509
发表时间：
2022-01
期刊：
PLoS biology
影响因子：
9.8
作者：
Yang Q;Zhou G;Noto T;Templer JW;Schuele SU;Rosenow JM;Lane G;Zelano C
通讯作者：
Zelano C

The effect of seizure spread to the amygdala on respiration and onset of ictal central apnea.

DOI：
10.3171/2019.1.jns183157
发表时间：
2020-05-01
期刊：
Journal of neurosurgery
影响因子：
4.1
作者：
Nobis WP;González Otárula KA;Templer JW;Gerard EE;VanHaerents S;Lane G;Zhou G;Rosenow JM;Zelano C;Schuele S
通讯作者：
Schuele S

Assessment of direct knowledge of the human olfactory system.