Small heat shock proteins: front-line defenders and therapeutic targets

小热休克蛋白：前线防御者和治疗靶点

• 批准号: FT110100586
• 负责人: Prof Heath Ecroyd
• 金额: $ 46.86万
• 依托单位: University of Wollongong
• 依托单位国家: 澳大利亚
• 项目类别: ARC Future Fellowships
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-05-31 至 2018-03-30
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/FT110100586
• 关键词: Small; heat; shock; proteins; front

Small heat-shock chaperone proteins play a key role as front line defenders against protein aggregation, a process linked to ageing and disease. This project spans fields from protein chemistry to cell biology to generate an unprecedented insight into the links between the structure, function and therapeutic potential of these chaperone proteins.

小的热休克分子伴侣蛋白作为对抗蛋白质聚集的前线防御者发挥着关键作用，蛋白质聚集是一个与衰老和疾病有关的过程。该项目涵盖了从蛋白质化学到细胞生物学的各个领域，对这些分子伴侣蛋白的结构、功能和治疗潜力之间的联系产生了前所未有的见解。