Evaluation of the Mechanical Properties of the Bone-Implant Interface

骨-种植体界面的机械性能评估

• 批准号: RGPIN-2020-04621
• 负责人: Westover, Lindsey
• 金额: $ 1.68万
• 依托单位: University of Alberta
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=717234
• 关键词: Evaluation; Mechanical; Properties; Bone; Implant

Skin-penetrating bone-anchored implants are used in a variety of applications to provide tremendous functional benefits to patients. Globally, the dental implant industry has been valued at 5.08 billion USD where implants are used for replacing single teeth, for larger prostheses, and for full dental arches. Bone-anchored-hearing-aids have been available since the 1970s with more than 150,000 global users. Further, bone-anchored implants are used to reconstruct facial features in the orbital, nasal, and auricular regions and in jaw reconstruction using fibular grafts. These implants rely on the structural integrity of the bone-implant interface through a process called osseointegration. Similar concepts of interface integrity can be applied to natural interfaces, such as the bone-ligament-tooth complex of a natural tooth. In this case, the interface is the periodontal ligament (PDL) which connects the tooth root to the surrounding bone. It is estimated that Canadian expenditures on dental services in 2015 reached $13.6 billion. The PDL is a vital structure in dental health with critical functions in tooth stability and orthodontic movement. Noninvasively evaluating the interface integrity in both bone-anchored implants and natural teeth is critically important to understanding the behaviour of these structures in a clinical setting. For the bone-implant interface, this is important to prescribe loading, identify the risk of failure, and monitor the long-term implant health. Similarly, evaluating the complex tooth-ligament-bone structure is important in diagnosing periodontal disease, assessing the PDL after trauma, and understanding the changes associated with orthodontic treatment. The long-term goal of this program is to advance the understanding of the mechanical and biological behaviour of interface tissues in bone-anchored implants and natural teeth. The short-term objectives will focus on: O1: Evaluating osseointegration at the bone implant interface in implants used for craniofacial reconstruction and dental implants O2: Evaluating the integrity of the PDL in natural teeth O3: Validation of the analytical modeling approach The proposed approach uses an acceleration measurement during an impact with the mechanical biological system combined with an analytical model. Numerical analysis is used to couple the experimental measurement with the model to estimate the interface properties. The analytical models are developed through laboratory testing and further evaluated with real patient data. The models will be validated through detailed finite element models and destructive mechanical testing. This research program will provide valuable insight into relevant questions such as appropriate timelines for implant loading, detection of implant failure, and assessment of various stages of tooth stability. The validation of the approach will strengthen the utility of the technique while providing a strong foundation for further research.

皮肤穿透骨锚式植入物可用于多种应用，为患者提供巨大的功能益处。全球范围内，牙种植体行业价值达 50.8 亿美元，种植体用于替换单颗牙齿、较大的假牙和全牙弓。骨锚式助听器自 20 世纪 70 年代以来就已面世，全球用户超过 150,000 人。此外，骨锚式植入物还用于重建眼眶、鼻腔和耳廓区域的面部特征，以及使用腓骨移植物重建颌骨。这些植入物通过称为骨整合的过程依赖于骨-植入物界面的结构完整性。 界面完整性的类似概念可以应用于自然界面，例如天然牙齿的骨-韧带-牙齿复合体。在这种情况下，界面是将牙根与周围骨骼连接起来的牙周韧带（PDL）。据估计，2015年加拿大在牙科服务方面的支出达到136亿加元。 PDL 是牙齿健康的重要结构，在牙齿稳定性和正畸运动方面具有关键功能。 无创评估骨锚式种植体和天然牙的界面完整性对于了解这些结构在临床环境中的行为至关重要。对于骨-种植体界面，这对于规定负载、识别失败风险和监测长期种植体健康状况非常重要。同样，评估复杂的牙齿-韧带-骨结构对于诊断牙周病、评估创伤后的 PDL 以及了解与正畸治疗相关的变化也很重要。 该计划的长期目标是增进对骨锚式种植体和天然牙界面组织的机械和生物行为的理解。短期目标将集中于： O1：评估用于颅面重建和牙科种植的种植体骨种植体界面的骨整合 O2：评估天然牙 PDL 的完整性 O3：分析建模方法的验证 所提出的方法使用机械生物系统撞击期间的加速度测量并结合分析模型。数值分析用于将实验测量与模型结合起来以估计界面特性。分析模型是通过实验室测试开发的，并根据真实患者数据进行进一步评估。这些模型将通过详细的有限元模型和破坏性机械测试进行验证。 该研究计划将为相关问题提供有价值的见解，例如种植体加载的适当时间表、种植体失败的检测以及牙齿稳定性各个阶段的评估。该方法的验证将增强该技术的实用性，同时为进一步的研究提供坚实的基础。