Evaluation of the Mechanical Properties of the Bone-Implant Interface

骨-种植体界面的机械性能评估

• 批准号: RGPIN-2020-04621
• 负责人: Westover, Lindsey
• 金额: $ 1.68万
• 依托单位: University of Alberta
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2022
• 资助国家: 加拿大
• 起止时间: 2022-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=760309
• 关键词: Evaluation; Mechanical; Properties; Bone; Implant

Skin-penetrating bone-anchored implants are used in a variety of applications to provide tremendous functional benefits to patients. Globally, the dental implant industry has been valued at 5.08 billion USD where implants are used for replacing single teeth, for larger prostheses, and for full dental arches. Bone-anchored-hearing-aids have been available since the 1970s with more than 150,000 global users. Further, bone-anchored implants are used to reconstruct facial features in the orbital, nasal, and auricular regions and in jaw reconstruction using fibular grafts. These implants rely on the structural integrity of the bone-implant interface through a process called osseointegration. Similar concepts of interface integrity can be applied to natural interfaces, such as the bone-ligament-tooth complex of a natural tooth. In this case, the interface is the periodontal ligament (PDL) which connects the tooth root to the surrounding bone. It is estimated that Canadian expenditures on dental services in 2015 reached $13.6 billion. The PDL is a vital structure in dental health with critical functions in tooth stability and orthodontic movement. Noninvasively evaluating the interface integrity in both bone-anchored implants and natural teeth is critically important to understanding the behaviour of these structures in a clinical setting. For the bone-implant interface, this is important to prescribe loading, identify the risk of failure, and monitor the long-term implant health. Similarly, evaluating the complex tooth-ligament-bone structure is important in diagnosing periodontal disease, assessing the PDL after trauma, and understanding the changes associated with orthodontic treatment. The long-term goal of this program is to advance the understanding of the mechanical and biological behaviour of interface tissues in bone-anchored implants and natural teeth. The short-term objectives will focus on: O1: Evaluating osseointegration at the bone implant interface in implants used for craniofacial reconstruction and dental implants O2: Evaluating the integrity of the PDL in natural teeth O3: Validation of the analytical modeling approach The proposed approach uses an acceleration measurement during an impact with the mechanical biological system combined with an analytical model. Numerical analysis is used to couple the experimental measurement with the model to estimate the interface properties. The analytical models are developed through laboratory testing and further evaluated with real patient data. The models will be validated through detailed finite element models and destructive mechanical testing. This research program will provide valuable insight into relevant questions such as appropriate timelines for implant loading, detection of implant failure, and assessment of various stages of tooth stability. The validation of the approach will strengthen the utility of the technique while providing a strong foundation for further research.

皮肤穿透骨锚定植入物用于各种应用，为患者提供巨大的功能受益。在全球范围内，牙科种植体行业的价值为50.8亿美元，其中种植体用于替换单个牙齿，用于较大的修复体和完整的牙弓。自20世纪70年代以来，骨锚式助听器已经在全球范围内拥有超过15万名用户。此外，骨锚定植入物用于重建眼眶、鼻部和耳部区域的面部特征，以及使用腓骨移植物重建颌骨。这些种植体通过称为骨整合的过程依赖于骨-种植体界面的结构完整性。 界面完整性的类似概念可以应用于天然界面，例如天然牙齿的骨-韧带-牙齿复合体。在这种情况下，界面是牙周膜（PDL），它将牙根连接到周围的骨骼。据估计，2015年加拿大在牙科服务上的支出达到136亿加元。PDL是牙齿健康的重要结构，在牙齿稳定和正畸移动中具有重要功能。 非侵入性地评估骨锚定种植体和天然牙的界面完整性对于了解这些结构在临床环境中的行为至关重要。对于骨-植入物界面，这对于规定载荷、识别失效风险和监测长期植入物健康状况非常重要。同样，评估复杂的牙齿-韧带-骨结构在诊断牙周病、评估创伤后PDL以及了解与正畸治疗相关的变化方面也很重要。该计划的长期目标是促进对骨锚定种植体和天然牙齿中界面组织的力学和生物学行为的理解。短期目标将集中在：O 1：评价用于颅面重建和牙科种植体的种植体中骨种植体界面处的骨整合O2：评价天然牙齿中PDL的完整性O3：分析建模方法的验证所提出的方法在与机械生物系统结合分析模型的冲击期间使用加速度测量。采用数值分析将实验测量与模型相结合来估计界面性质。通过实验室测试开发分析模型，并使用真实的患者数据进行进一步评估。模型将通过详细的有限元模型和破坏性机械测试进行验证。这项研究计划将为相关问题提供有价值的见解，例如种植体加载的适当时间表，种植体失败的检测和牙齿稳定性的各个阶段的评估。该方法的验证将加强该技术的实用性，同时为进一步的研究提供了坚实的基础。