Impact of natural biologics on the stress response: relationship between fear and appetitive brain circuits

天然生物制剂对压力反应的影响：恐惧与食欲脑回路之间的关系

• 批准号: RGPIN-2020-06518
• 负责人: Merali, Zul
• 金额: $ 2.4万
• 依托单位: Carleton University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=717849
• 关键词: Impact; natural; biologics; stress; response

Specific objectives: While stressors and other highly salient stimuli provoke a wide range of hormonal neurotransmitter and behavioral responses, the underlying triggering mechanisms remain unclear. Increased attention is being focused on the role of several peptidergic systems, in the mediation of these behavioral and physiological responses and in the quest for biologics capable of mitigating those responses. In keeping with our long-term research program, the proposed studies will address the following contentions, initially focused on stressors and then to other biologically salient events: 1. BBs and CRF serve as CNS regulators with integrative properties coordinating the organism's neuroendocrine and behavioral responses to stressors. 2. Stressor exposure will impact motivational and/or emotional states in a variable fashion depending on the type of stressor employed. 3. A systemic challenge (or stressor, e.g. bacterial endotoxin, LPS) will provoke behavioral and neurochemical alterations reminiscent of those elicited by psychogenic stressors. 4. Exposure to an appetitive stimulus will activate some of the same peptidegic circuits as those activated by a aversive stimuli. 5. The effects of these aversive or appetitive events will be attenuated by specific plant-derived biologics, including active ingredients from the neotropical vine Souroubea Symptata Gilgi, and marijuana plant extracts (THC, CBD and/or the terpenes), through their action(s) on BBs and CRF system(s).

具体目标：虽然压力源和其他高度显着的刺激会引起广泛的激素神经递质和行为反应，但潜在的触发机制仍不清楚。人们越来越多地关注几种肽能系统在这些行为和生理反应的介导中的作用，以及寻找能够减轻这些反应的生物制剂。 为了与我们的长期研究计划保持一致，拟议的研究将解决以下争论，首先关注压力源，然后关注其他生物学显着事件： 1. BB 和 CRF 作为 CNS 调节剂，具有协调生物体神经内分泌和对应激源的行为反应的综合特性。 2. 压力源暴露将以不同的方式影响动机和/或情绪状态，具体取决于所使用的压力源的类型。 3. 全身性挑战（或压力源，例如细菌内毒素、LPS）将引起行为和神经化学改变，类似于心因性压力源引起的变化。 4. 暴露于食欲刺激会激活一些与厌恶刺激所激活的肽回路相同的肽回路。 5. 这些厌恶或食欲事件的影响将被特定的植物源生物制剂通过其对 BB 和 CRF 系统的作用而减弱，这些生物制剂包括来自新热带藤本植物 Souroubea Symptata Gilgi 的活性成分和大麻植物提取物（THC、CBD 和/或萜烯）。