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Biomolecular Imaging System for Nanomedicine and Chemical Biology Applications in Pharmaceutical Sciences

用于制药科学中纳米医学和化学生物学应用的生物分子成像系统

基本信息

批准号：
RTI-2021-00633
负责人：
Frankel, Adam
金额：
$ 10.55万
依托单位：
University of British Columbia
依托单位国家：
加拿大
项目类别：
Research Tools and Instruments
财政年份：
2020
资助国家：
加拿大
起止时间：
2020-01-01 至 2021-12-31
项目状态：
已结题

来源：
https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=718201
关键词：
Biomolecular Imaging System Nanomedicine Chemical

项目摘要

The Nanomedicine and Chemical Biology research group within the Faculty of Pharmaceutical Sciences at the University of British Columbia is interested in rapidly expanding their imaging capabilities in various areas of research by acquiring a state-of-the-art laser scanner system. This laser scanning system, which will be housed in a research infrastructure cluster within the Pharmaceutical Sciences building on the UBC Vancouver campus to fulfill the diverse needs of our scientists, is versatile and essential equipment with the broadest range of quantitative imaging modalities currently available. In addition to chemiluminescence that is routinely used for protein detection on Western blots to identify specific proteins, another key feature unique for this laser scanner is its four-colour (blue, green, red, and near infrared) fluorescence detection and quantification that allows for multiplexed imaging for complex samples. The laser scanner is also capable of radioactive signal detection through filmless autoradiography with the widest linear dynamic currently available. All of these advanced imaging techniques will enable us to bring our science to life through the awesome power of molecular, cellular, and tissue visualization. The acquisition of this multi-use and multi-user laser imager will help elevate the excellence of our research team and provide accessible training opportunities for many Canadian researchers at all career levels.

不列颠哥伦比亚省大学药学院的纳米医学和化学生物学研究小组有兴趣通过获得最先进的激光扫描仪系统来快速扩展其在各个研究领域的成像能力。该激光扫描系统将安装在UBC温哥华校区药物科学大楼内的研究基础设施集群中，以满足我们科学家的各种需求，是目前可用的最广泛的定量成像模式的通用和必要设备。除了常规用于蛋白质检测以识别特定蛋白质的化学发光外，该激光扫描仪的另一个独特的关键功能是其四色（蓝色、绿色、红色和近红外）荧光检测和定量，允许对复杂样品进行多重成像。激光扫描仪还能够通过无胶片放射自显影进行放射性信号检测，具有目前可用的最宽线性动态。所有这些先进的成像技术将使我们能够通过分子，细胞和组织可视化的可怕力量将我们的科学带入生活。购买这台多用途和多用户激光成像仪将有助于提升我们研究团队的卓越水平，并为所有职业水平的许多加拿大研究人员提供可访问的培训机会。