Molecular Plant-Virus Interactions: Defense and Counter-defense
分子植物-病毒相互作用:防御与反防御
基本信息
- 批准号:RGPIN-2020-06416
- 负责人:
- 金额:$ 4.23万
- 依托单位:
- 依托单位国家:加拿大
- 项目类别:Discovery Grants Program - Individual
- 财政年份:2020
- 资助国家:加拿大
- 起止时间:2020-01-01 至 2021-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Viral pathogens account for the largest proportion of newly emerging
plant diseases and threaten global food security. To combat viruses, plants
have evolved sophisticated defense mechanisms. In response, viruses have also
evolved virulence strategies to counteract host defense. The long-term goal of
our research program is to understand the complex virus-plant interactions, in
particular the co-evolutionary arms race between viruses and plants, for the
development of novel technologies to control viral diseases for sustainable
crop production. An increasing body of evidence suggests that RNA-targeted
immunity, which embraces RNA silencing, RNA decay and RNA quality control and
regulates endogenous gene expression, is a central defense to viral pathogens
in plants. These RNA immunity pathways may act in a hierarchical and concerted
mode to inhibit virus infection with RNA silencing as a master player. RNA
silencing, triggered by double-stranded RNA, is a fundamental,
sequence-specific mechanism conserved in all eukaryotes. Viruses encode viral
suppressors of RNA silencing (VSRs) that bind to cellular factors to cope with
RNA silencing. Recently, we have found that VSRs also subvert RNA decay through
interactions with key cellular decay pathway components to promote viral
infection and autophagy plays contrasting roles (predominantly antiviral) in
virus infection by regulating VSRs. As VSRs are highly diverse in sequence,
they appear to interact with host proteins to execute their function. In this
proposed research, we will identify host proteins that are recruited via
interactions with VSRs to function specifically for RNA-targeted antiviral
immunity rather than for endogenous gene regulation. We will further characterize
their mechanistic details in the resistance-signaling pathway and elucidate how
viruses interfere the antiviral function of these cellular factors
using classical, molecular and cell biology techniques. Another
emerging crucial antiviral defense is host factor-mediated recessive resistance.
The vast majority of plant viruses have a small positive-sense, single-stranded
RNA genome with very limited coding capacity. Thus, the invading virus depends
on a number of host factors to establish its infection and disruption of the
host factor-virus interaction leads to genetic resistance. Among a number of
host factors identified so far, the eukaryotic translation initiation factor 4E
(eIF4E) or its isoform eIF(iso)4E is outstanding as genetic lesions of eIF4E
or eIF(iso)4E may confer immunity to a number of viruses,
particularly potyviruses. Unfortunately, the underlying mechanism still remains
elusive. Recently, we have found that eIF4E-mediated resistance may
interlink with RNA-targeted immunity. In this proposed research, we will also
molecularly understand and functionally characterize the eIF4E interactome in the context of virus
infection, particularly the role of RNA-target immunity in eIF4E-mediated
resistance using genetic, molecular and biochemical approaches.
病毒性病原体占新出现病原体的最大比例
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Wang, Aiming其他文献
PHLPP1 inhibits the growth and aerobic glycolysis activity of human ovarian granular cells through inactivating AKT pathway.
- DOI:
10.1186/s12905-023-02872-5 - 发表时间:
2024-01-06 - 期刊:
- 影响因子:2.5
- 作者:
Yang, Xiaoyan;Min, A.;Gegen, Tana;Daoerji, Badema;Zheng, Yue;Wang, Aiming - 通讯作者:
Wang, Aiming
Identification and molecular characterization of two naturally occurring Soybean mosaic virus isolates that are closely related but differ in their ability to overcome Rsv4 resistance
- DOI:
10.1016/j.virusres.2008.08.010 - 发表时间:
2008-12-01 - 期刊:
- 影响因子:5
- 作者:
Gagarinova, Alla G.;Babu, Mohan;Wang, Aiming - 通讯作者:
Wang, Aiming
A plant RNA virus inhibits NPR1 sumoylation and subverts NPR1-mediated plant immunity.
- DOI:
10.1038/s41467-023-39254-2 - 发表时间:
2023-06-16 - 期刊:
- 影响因子:16.6
- 作者:
Liu, Jiahui;Wu, Xiaoyun;Fang, Yue;Liu, Ye;Bello, Esther Oreofe;Li, Yong;Xiong, Ruyi;Li, Yinzi;Fu, Zheng Qing;Wang, Aiming;Cheng, Xiaofei - 通讯作者:
Cheng, Xiaofei
Fault Diagnosis under Variable Working Conditions Based on STFT and Transfer Deep Residual Network
- DOI:
10.1155/2020/1274380 - 发表时间:
2020-05-04 - 期刊:
- 影响因子:1.6
- 作者:
Du, Yan;Wang, Aiming;Meng, Guoying - 通讯作者:
Meng, Guoying
The C-terminal region of the Turnip mosaic virus P3 protein is essential for viral infection via targeting P3 to the viral replication complex
- DOI:
10.1016/j.virol.2017.07.016 - 发表时间:
2017-10-01 - 期刊:
- 影响因子:3.7
- 作者:
Cui, Xiaoyan;Yaghmaiean, Hoda;Wang, Aiming - 通讯作者:
Wang, Aiming
Wang, Aiming的其他文献
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{{ truncateString('Wang, Aiming', 18)}}的其他基金
Molecular Plant-Virus Interactions: Defense and Counter-defense
分子植物-病毒相互作用:防御与反防御
- 批准号:
RGPIN-2020-06416 - 财政年份:2022
- 资助金额:
$ 4.23万 - 项目类别:
Discovery Grants Program - Individual
Molecular Plant-Virus Interactions: Defense and Counter-defense
分子植物-病毒相互作用:防御与反防御
- 批准号:
RGPIN-2020-06416 - 财政年份:2021
- 资助金额:
$ 4.23万 - 项目类别:
Discovery Grants Program - Individual
Uncovering Molecular Mechanisms Underlying Cell-to-Cell Movement and Long-Distance Trafficking of Viruses in Plants
揭示植物细胞间运动和病毒远距离贩运的分子机制
- 批准号:
RGPIN-2015-05117 - 财政年份:2019
- 资助金额:
$ 4.23万 - 项目类别:
Discovery Grants Program - Individual
Uncovering Molecular Mechanisms Underlying Cell-to-Cell Movement and Long-Distance Trafficking of Viruses in Plants
揭示植物细胞间运动和病毒远距离贩运的分子机制
- 批准号:
RGPIN-2015-05117 - 财政年份:2018
- 资助金额:
$ 4.23万 - 项目类别:
Discovery Grants Program - Individual
Uncovering Molecular Mechanisms Underlying Cell-to-Cell Movement and Long-Distance Trafficking of Viruses in Plants
揭示植物细胞间运动和病毒远距离贩运的分子机制
- 批准号:
RGPIN-2015-05117 - 财政年份:2017
- 资助金额:
$ 4.23万 - 项目类别:
Discovery Grants Program - Individual
Uncovering Molecular Mechanisms Underlying Cell-to-Cell Movement and Long-Distance Trafficking of Viruses in Plants
揭示植物细胞间运动和病毒远距离贩运的分子机制
- 批准号:
RGPIN-2015-05117 - 财政年份:2016
- 资助金额:
$ 4.23万 - 项目类别:
Discovery Grants Program - Individual
Uncovering Molecular Mechanisms Underlying Cell-to-Cell Movement and Long-Distance Trafficking of Viruses in Plants
揭示植物细胞间运动和病毒远距离贩运的分子机制
- 批准号:
RGPIN-2015-05117 - 财政年份:2015
- 资助金额:
$ 4.23万 - 项目类别:
Discovery Grants Program - Individual
Towards a better understanding of molecular virus-plant interactions: componenets and intracellular trafficking of viral genome translation/replication complexes
更好地理解分子病毒与植物的相互作用:病毒基因组翻译/复制复合物的成分和细胞内运输
- 批准号:
312251-2010 - 财政年份:2014
- 资助金额:
$ 4.23万 - 项目类别:
Discovery Grants Program - Individual
Towards a better understanding of molecular virus-plant interactions: componenets and intracellular trafficking of viral genome translation/replication complexes
更好地理解分子病毒与植物的相互作用:病毒基因组翻译/复制复合物的成分和细胞内运输
- 批准号:
312251-2010 - 财政年份:2013
- 资助金额:
$ 4.23万 - 项目类别:
Discovery Grants Program - Individual
Towards a better understanding of molecular virus-plant interactions: componenets and intracellular trafficking of viral genome translation/replication complexes
更好地理解分子病毒与植物的相互作用:病毒基因组翻译/复制复合物的成分和细胞内运输
- 批准号:
312251-2010 - 财政年份:2012
- 资助金额:
$ 4.23万 - 项目类别:
Discovery Grants Program - Individual
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