Rampable Intraoperative Magnetic Resonance Imaging

可倾斜术中磁共振成像

• 批准号: 555261-2020
• 负责人: Martin, Melanie
• 金额: $ 7.29万
• 依托单位: University of Winnipeg
• 依托单位国家: 加拿大
• 项目类别: Alliance Grants
• 财政年份: 2021
• 资助国家: 加拿大
• 起止时间: 2021-01-01 至 2022-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=721358
• 关键词: Rampable; Intraoperative; Magnetic; Resonance; Imaging

MRI scanners generate exquisitely detailed images of brain and spinal cord anatomy and pathology. Althoughan engineering challenge, the placement of MRI systems in the operating room will revolutionize neurosurgicalcare. The first commercial iMRI systems were developed by GE based on a 0.5 Tesla magnet with Brighamand Women's hospital in Boston. In 1988 a group in Winnipeg (IMRIS) developed an iMRI system based on a1.5 Tesla magnet which overcame many of the difficult issues discovered with the GE system. The iMRItechnology enabled neurosurgeons to improve surgeries and outcomes. Intraoperative MRI has also identified asignificant number of patients who harboured unsuspected, residual tumour at the end of surgery, thus sparingthem the discomfort and expense of reoperation.The major problem with the IMRIS intraoperative system which is the market leader it was is too expensive.An even more serious problem was that the cost of renovation to the hospital was much more expensive andrequired operating suites to be closed for months during this renovation.Our new concept is to base the iMRI on a cryogen free magnet which can be ramped to 1 tesla and is stable atthis field in 10 minutes. The magnet will be made with Magnesium Diboride (MgB2) which is a hightemperature superconducting material. The magnet will be continually connected to a power supply and so willnot require to be persistent allowing for the rapid ramp rate.The objective of the new design is to have an intra-operative MRI that take 2 weeks to install in a standardhospital surgical suite which can provide images of the same quality as a 1.5 Tesla commercial MRI on 2012 inthe same time. The important research factor being developed in this proposal is to obtain image qualityequivalent or better to what was obtained with the 1.5 tesla IMRIS systems. It is well known that the signal tonoise ratio (SNR) increases linearly with field strength so a 1 Tesla magnet will have about 60% of the SNR tothat of 1.5 Tesla magnet. We will develop RF coils and AI techniques to improve image quality.

磁共振成像扫描仪生成精细详细的大脑和脊髓解剖和病理图像。尽管面临着工程上的挑战，但在手术室中放置MRI系统将彻底改变神经外科护理。第一个商业化的iMRI系统是由通用电气公司与波士顿的Brigamand妇女医院开发的，基于0.5特斯拉的磁铁。1988年，温尼伯的一个小组（IMRIS）开发了一种基于1.5特斯拉磁体的iMRI系统，该系统克服了GE系统发现的许多困难问题。iMRI技术使神经外科医生能够改善手术和结果。术中MRI还发现了大量患者在手术结束时存在未被怀疑的残留肿瘤，IMRIS术中系统是市场的领导者，其主要问题是太贵，更严重的问题是医院的翻修费用要贵得多，需要手术室关闭数月我们的新概念是将iMRI建立在一个无冷冻剂的磁铁上，它可以上升到1特斯拉，并且在10分钟内稳定在这个磁场上。磁体将由二硼化镁（MgB2）制成，这是一种高温超导材料。磁体将持续连接到电源，因此不需要持续，允许快速的斜坡率。新设计的目标是拥有一个术中MRI，需要2周时间安装在标准医院手术室中，可以提供与2012年1.5特斯拉商业MRI相同质量的图像。在这项提案中正在开发的重要研究因素是获得与1.5特斯拉IMRIS系统相同或更好的图像质量。众所周知，信号噪声比（SNR）随磁场强度线性增加，因此1特斯拉磁体的SNR约为1.5特斯拉磁体的SNR的60%。我们将开发RF线圈和AI技术，以提高图像质量。