Rampable Intraoperative Magnetic Resonance Imaging

可倾斜术中磁共振成像

• 批准号: 555261-2020
• 负责人: Martin, Melanie
• 金额: $ 7.29万
• 依托单位: University of Winnipeg
• 依托单位国家: 加拿大
• 项目类别: Alliance Grants
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=705605
• 关键词: Rampable; Intraoperative; Magnetic; Resonance; Imaging

MRI scanners generate exquisitely detailed images of brain and spinal cord anatomy and pathology. Although an engineering challenge, the placement of MRI systems in the operating room will revolutionize neurosurgical care. The first commercial iMRI systems were developed by GE based on a 0.5 Tesla magnet with Brigham and Women's hospital in Boston. In 1988 a group in Winnipeg (IMRIS) developed an iMRI system based on a 1.5 Tesla magnet which overcame many of the difficult issues discovered with the GE system. The iMRI technology enabled neurosurgeons to improve surgeries and outcomes. Intraoperative MRI has also identified a significant number of patients who harboured unsuspected, residual tumour at the end of surgery, thus sparing them the discomfort and expense of reoperation. The major problem with the IMRIS intraoperative system which is the market leader it was is too expensive. An even more serious problem was that the cost of renovation to the hospital was much more expensive and required operating suites to be closed for months during this renovation. Our new concept is to base the iMRI on a cryogen free magnet which can be ramped to 1 tesla and is stable at this field in 10 minutes. The magnet will be made with Magnesium Diboride (MgB2) which is a high temperature superconducting material. The magnet will be continually connected to a power supply and so will not require to be persistent allowing for the rapid ramp rate. The objective of the new design is to have an intra-operative MRI that take 2 weeks to install in a standard hospital surgical suite which can provide images of the same quality as a 1.5 Tesla commercial MRI on 2012 in the same time. The important research factor being developed in this proposal is to obtain image quality equivalent or better to what was obtained with the 1.5 tesla IMRIS systems. It is well known that the signal to noise ratio (SNR) increases linearly with field strength so a 1 Tesla magnet will have about 60% of the SNR to that of 1.5 Tesla magnet. We will develop RF coils and AI techniques to improve image quality.

磁共振成像扫描仪生成精细详细的大脑和脊髓解剖和病理图像。虽然 作为一项工程挑战，在手术室中放置MRI系统将彻底改变神经外科 在乎第一个商业化的iMRI系统是由GE基于0.5特斯拉磁铁与Brigham开发的 和波士顿的妇女医院1988年，温尼伯的一个小组（IMRIS）开发了一种基于 1.5特斯拉磁铁，克服了GE系统发现的许多困难问题。iMRI 技术使神经外科医生能够改善手术和结果。术中MRI也发现了一个 大量患者在手术结束时未被怀疑存在残留肿瘤，因此 再次手术的痛苦和费用。 IMRIS术中系统是市场的领导者，它的主要问题是太贵了。 一个更严重的问题是，医院的装修费用要昂贵得多， 要求手术室在翻修期间关闭数月。 我们的新概念是将iMRI基于无冷冻剂磁体，该磁体可以倾斜至1特斯拉，并且在 10分钟后到达这里磁铁将由二硼化镁（MgB2）制成，这是一种高强度的磁铁。 高温超导材料磁铁将持续连接到电源， 不需要持续，允许快速的斜坡速率。 新设计的目标是使术中MRI需要2周时间安装在标准 2012年，医院外科手术室可以提供与1.5特斯拉商用MRI相同质量的图像， 同时还研究与讨论在这项建议中正在开发的重要研究因素是获得图像质量 相当于或优于1.5特斯拉IMRIS系统所获得的。众所周知， 噪声比（SNR）随场强线性增加，因此1特斯拉磁体将具有约60%的SNR， 1.5特斯拉磁铁我们将开发RF线圈和AI技术，以提高图像质量。