Pairing pooled CRISPR/Cas9 screens with high-resolution multiplexed approaches to study cell competition and pre-malignancy in breast and skin epithelium

将混合 CRISPR/Cas9 筛选与高分辨率多重方法配对，研究乳腺和皮肤上皮细胞的细胞竞争和癌前病变

• 批准号: 458127
• 负责人: Teng Katie
• 金额: $ 7.65万
• 依托单位: Sinai Health System (Toronto)
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2021
• 资助国家: 加拿大
• 起止时间: 2021-11-01 至 2024-11-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=458127&lang=en
• 关键词: Breast Cancer; Cell Competition; Crispr/Cas9; Functional Genomics; Genetics; Imaging Mass Cytometry; Pre-Malignancy; Single-Cell Spatial Phenotyping; Skin Cancer; Tumour Immune Microenvironment

Many healthy adult tissues, such as the breast and skin, contain cells that carry mutations that accumulate with age and are linked to cancer development. Although many cells are known to be mutated in normal tissues, mechanisms such as cell competition a

许多健康的成人组织，如乳房和皮肤，含有携带突变的细胞，这些突变随着年龄的增长而积累，并与癌症的发展有关。尽管已知许多细胞在正常组织中会发生突变，但细胞竞争等机制仍然存在。