Advancing multilayer surface disinfection technologies for modern pandemic protection

推进多层表面消毒技术以实现现代流行病防护

• 批准号: 570425-2021
• 负责人: Mitra, SushantaK
• 金额: $ 27.77万
• 依托单位: University of Waterloo
• 依托单位国家: 加拿大
• 项目类别: Alliance Grants
• 财政年份: 2021
• 资助国家: 加拿大
• 起止时间: 2021-01-01 至 2022-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=723172
• 关键词: Advancing; multilayer; surface; disinfection; technologies

Pathogens can persist on surfaces for several days, necessitating cleaning between uses to prevent disease transmission. However, conventional surface disinfection methods when used alone are impractical, short-lived, and/or too targeted for use in large-scale, high-traffic, and frequently contaminated areas such as hospitals and industrial facilities. Furthermore, common methods such as chemical sprays negatively impact health and the environment, limiting their use in healthcare facilities where patients are already vulnerable. Multilayer disinfection strategies can be used to overcome these challenges, while also preventing new variants from gaining resistance against a single disinfection agent. This project aims to develop and test a new multilayer disinfection strategy that integrates two innovative technologies, nanoparticles containing quats and ozone nanobubbles, to increase disinfection efficacy and kill a wider range of pathogens for a healthier community. We will test this integrated approach under lab conditions using model viruses and bacteria, as well as inside healthcare facilities to better understand its effectiveness in real-world settings. This partnership among industry, healthcare, and academia will help advance these technologies so that they can be adopted on a wide scale.Advanced surface disinfection will become the new norm in Canada going forward. Such multilayer approaches will prevent outbreaks and associated lockdowns, which will in turn help strengthen the Canadian economy, increase societal resiliency, and safeguard Canadians against future pandemics.

病原体可以在表面上持续数天，因此需要在使用之间进行清洁以防止疾病传播。然而，传统的表面消毒方法在单独使用时是不切实际的、短暂的和/或对于在大规模、高流量和频繁污染的区域（例如医院和工业设施）中使用而言太有针对性。此外，化学喷雾等常用方法对健康和环境产生负面影响，限制了它们在患者已经脆弱的医疗机构中的使用。多层消毒策略可用于克服这些挑战，同时还可防止新变体获得对单一消毒剂的抗性。该项目旨在开发和测试一种新的多层消毒策略，该策略整合了两种创新技术，即含有季铵化合物的纳米颗粒和臭氧纳米气泡，以提高消毒效果并杀死更广泛的病原体，从而建立一个更健康的社区。我们将在实验室条件下使用模型病毒和细菌以及医疗机构内部测试这种综合方法，以更好地了解其在现实环境中的有效性。工业界、医疗保健界和学术界之间的这种伙伴关系将有助于推动这些技术的发展，使它们能够被广泛采用。先进的表面消毒将成为加拿大未来的新规范。这种多层次的方法将防止疫情爆发和相关的封锁，这反过来将有助于加强加拿大经济，提高社会弹性，并保护加拿大人免受未来流行病的影响。