Composition of the cardiac IKs channel complex as a determinant of the KCNQ1 mutation disease phenotype

心脏 IK 通道复合物的组成作为 KCNQ1 突变疾病表型的决定因素

• 批准号: 466586
• 负责人: Chan Magnus
• 金额: $ 1.27万
• 依托单位: University of British Columbia
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2021
• 资助国家: 加拿大
• 起止时间: 2021-12-01 至 2022-12-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=466586&lang=en
• 关键词: Arrhythmia; Atrial Fibrillation; Gene Expression; Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes; Ion Channels; Long Qt Syndrome; Microelectrode Array; Mutations; Patch Clamp; Potassium Currents

In the heart, KCNQ1 (Q1) is a potassium pore which associates with the regulatory subunit KCNE1 to form the I ion channel complex. I is essential in maintaining cardiac rhythm as it is responsible for relaxing cardiac cells and terminating the hearts cont

在心脏中，KCNQ1 （Q1）是一个钾孔，它与调控亚基KCNE1结合形成I离子通道复合物。I对维持心律至关重要，因为它负责放松心肌细胞和终止心脏循环