Medicine by Design

干细胞可以用来治疗和治愈许多慢性退行性疾病，这些疾病给社会带来了昂贵的负担。综合团队将利用多伦多在干细胞生物学、计算生物学、成像、纳米技术、生物医学工程以及细胞和器官移植方面的成熟优势，在三个支柱上带来变革性的临床和社会经济影响：1)设计带有集成记者和控制电路的细胞，以实现对细胞命运和功能的控制；2)使用设计细胞、材料和技术来制造用于药物发现、生理过程询问和组织替代的功能性复杂组织；以及3)开发体外工程器官，以加速移植。干细胞可以用来治疗和治愈许多慢性退行性疾病，这些疾病给社会带来了昂贵的负担。综合团队将利用多伦多在干细胞生物学、计算生物学、成像、纳米技术、生物医学工程以及细胞和器官移植方面的成熟优势，在三个支柱上带来变革性的临床和社会经济影响：1)设计带有集成记者和控制电路的细胞，以实现对细胞命运和功能的控制；2)使用设计细胞、材料和技术来制造用于药物发现、生理过程询问和组织替代的功能性复杂组织；以及3)开发体外工程器官，以加速移植。干细胞可以用来治疗和治愈许多慢性退行性疾病，这些疾病给社会带来了昂贵的负担。综合团队将利用多伦多在干细胞生物学、计算生物学、成像、纳米技术、生物医学工程以及细胞和器官移植方面的成熟优势，在三个支柱上带来变革性的临床和社会经济影响：1)设计带有集成记者和控制电路的细胞，以实现对细胞命运和功能的控制；2)使用设计细胞、材料和技术来制造用于药物发现、生理过程询问和组织替代的功能性复杂组织；以及3)开发体外工程器官，以加速移植。

Stem cells can be used to treat and cure many chronic degenerative diseases that present a costly burden to society. Integrated teams will leverage Toronto’s established strengths in stem cell biology, computational biology, imaging, nanotechnology, biomedical engineering, and cell and organ transplantation to deliver transformative clinical and socio-economic impacts across three pillars: 1)Design cells with integrated reporters and control circuits to enable control of cell fate and function; 2)Use designer cells, materials and technologies to formulate functional complex tissues for drug discovery, physiologic process interrogation and tissue replacement; and 3) Develop ex-vivo engineered organs to accelerate transplantation. Stem cells can be used to treat and cure many chronic degenerative diseases that present a costly burden to society. Integrated teams will leverage Toronto’s established strengths in stem cell biology, computational biology, imaging, nanotechnology, biomedical engineering, and cell and organ transplantation to deliver transformative clinical and socio-economic impacts across three pillars: 1)Design cells with integrated reporters and control circuits to enable control of cell fate and function; 2)Use designer cells, materials and technologies to formulate functional complex tissues for drug discovery, physiologic process interrogation and tissue replacement; and 3) Develop ex-vivo engineered organs to accelerate transplantation. Stem cells can be used to treat and cure many chronic degenerative diseases that present a costly burden to society. Integrated teams will leverage Toronto’s established strengths in stem cell biology, computational biology, imaging, nanotechnology, biomedical engineering, and cell and organ transplantation to deliver transformative clinical and socio-economic impacts across three pillars: 1)Design cells with integrated reporters and control circuits to enable control of cell fate and function; 2)Use designer cells, materials and technologies to formulate functional complex tissues for drug discovery, physiologic process interrogation and tissue replacement; and 3) Develop ex-vivo engineered organs to accelerate transplantation.