Canada Research Chair In Structural Biology

加拿大结构生物学研究主席

• 批准号: CRC-2016-00259
• 负责人: Stetefeld, Jörg
• 金额: $ 14.57万
• 依托单位: University of Manitoba
• 依托单位国家: 加拿大
• 项目类别: Canada Research Chairs
• 财政年份: 2021
• 资助国家: 加拿大
• 起止时间: 2021-01-01 至 2022-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=729908
• 关键词: Canada; Research; Chair; Structural; Biology

A molecular understanding of the structure-property relationships of extracellular proteins involved in (i) the formation of dynamic high-order signaling complexes related to human disease and (ii) the establishment of unique S-layer assemblies from extremophilic archea is essential for the development of structure-based applications in the fields of biomedicine and biotechnology. The exploration of structural dynamics of proteins in cellular communication and cell-matrix signaling are of great biomedical importance. In a second avenue of research, we are exploiting S-layer coiled coils to design industry applicable monitoring and remediation tools. The development of structure-guided applications based on the unique features of coiled-coil nanotubes is a new approach in application-driven research. We will continue to apply and develop further an integrated research program combining high-resolution structural biology techniques, with various biophysical and functional approaches.

从分子水平上理解细胞外蛋白质的结构-性质关系，对于在生物医学和生物技术领域发展基于结构的应用是至关重要的。这些蛋白质参与了(I)与人类疾病相关的动态高阶信号复合体的形成和(Ii)从极端微生物群中建立独特的S层组件。蛋白质结构动力学在细胞通讯和细胞基质信号传递中的探索具有重要的生物医学意义。在第二个研究途径中，我们正在利用S层螺旋线圈来设计行业适用的监测和补救工具。基于螺旋螺旋纳米管的独特特性开发结构导向应用是应用驱动研究的一种新途径。我们将继续应用和进一步发展高分辨率结构生物学技术与各种生物物理和功能方法相结合的综合研究计划。