Canada Research Chair In Structural Biology

加拿大结构生物学研究主席

• 批准号: CRC-2016-00259
• 负责人: Stetefeld, Jörg
• 金额: $ 14.57万
• 依托单位: University of Manitoba
• 依托单位国家: 加拿大
• 项目类别: Canada Research Chairs
• 财政年份: 2021
• 资助国家: 加拿大
• 起止时间: 2021-01-01 至 2022-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=729908
• 关键词: Canada; Research; Chair; Structural; Biology

A molecular understanding of the structure-property relationships of extracellular proteins involved in (i) the formation of dynamic high-order signaling complexes related to human disease and (ii) the establishment of unique S-layer assemblies from extremophilic archea is essential for the development of structure-based applications in the fields of biomedicine and biotechnology. The exploration of structural dynamics of proteins in cellular communication and cell-matrix signaling are of great biomedical importance. In a second avenue of research, we are exploiting S-layer coiled coils to design industry applicable monitoring and remediation tools. The development of structure-guided applications based on the unique features of coiled-coil nanotubes is a new approach in application-driven research. We will continue to apply and develop further an integrated research program combining high-resolution structural biology techniques, with various biophysical and functional approaches.

对细胞外蛋白的结构-性质关系的分子理解，涉及(i)与人类疾病相关的动态高阶信号复合物的形成，（ii）从极端嗜酸性古菌中建立独特的s层组装，对于生物医学和生物技术领域中基于结构的应用的发展至关重要。探索细胞通讯和细胞基质信号传导中蛋白质的结构动力学具有重要的生物医学意义。在研究的第二方面，我们正在利用s层线圈来设计工业适用的监测和修复工具。基于线圈纳米管的独特特性，开发结构导向应用是应用驱动研究的新途径。我们将继续应用并进一步发展一个综合研究项目，结合高分辨率结构生物学技术，以及各种生物物理和功能方法。