Canada Research Chair In Structural Biology

加拿大结构生物学研究主席

• 批准号: CRC-2016-00259
• 负责人: Stetefeld, Jörg
• 金额: $ 14.57万
• 依托单位: University of Manitoba
• 依托单位国家: 加拿大
• 项目类别: Canada Research Chairs
• 财政年份: 2021
• 资助国家: 加拿大
• 起止时间: 2021-01-01 至 2022-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=729908
• 关键词: Canada; Research; Chair; Structural; Biology

A molecular understanding of the structure-property relationships of extracellular proteins involved in (i) the formation of dynamic high-order signaling complexes related to human disease and (ii) the establishment of unique S-layer assemblies from extremophilic archea is essential for the development of structure-based applications in the fields of biomedicine and biotechnology. The exploration of structural dynamics of proteins in cellular communication and cell-matrix signaling are of great biomedical importance. In a second avenue of research, we are exploiting S-layer coiled coils to design industry applicable monitoring and remediation tools. The development of structure-guided applications based on the unique features of coiled-coil nanotubes is a new approach in application-driven research. We will continue to apply and develop further an integrated research program combining high-resolution structural biology techniques, with various biophysical and functional approaches.

对胞外蛋白质结构-性质关系的分子理解对于生物医学和生物技术领域中基于结构的应用的发展是必不可少的，所述胞外蛋白质参与（i）与人类疾病相关的动态高阶信号复合物的形成和（ii）从极端古细菌建立独特的S层组装。蛋白质结构动力学在细胞通讯和细胞-基质信号传导中的研究具有重要的生物医学意义。在研究的第二个方面，我们正在利用S层线圈来设计行业适用的监测和补救工具。利用螺旋状纳米管的独特性质开发结构导向的应用是应用驱动研究的一条新途径。 我们将继续应用和进一步发展一个综合研究计划，将高分辨率结构生物学技术与各种生物物理和功能方法相结合。