Quasi-Elastic Light Scattering for in-depth protein and protein-complex characterization

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Research programs in the laboratories of the four applicants (Drs. Stetefeld, McKenna, O'Neil and Mark) are focused on investigating a variety of interesting biological systems including integral membrane protein channels, extremophilic S-layer components, viral nucleic acid recognition proteins and regulatory bacterial kinases. The common feature that links each of these research groups is the structural and functional characterization of specific protein samples and their potential ligands to investigate their role in regulating the biological systems of interest. Rapid advances in the field of structural biology have allowed the research groups included in this proposal to determine high-resolution three-dimensional images of protein-ligand complexes, and begin to characterize their biochemical function and mechanism in terms of key molecular features that dictate the interaction.