Prion Disease Research

朊病毒病研究

• 批准号: CRC-2017-00288
• 负责人: Gilch, Sabine
• 金额: $ 7.29万
• 依托单位: University of Calgary
• 依托单位国家: 加拿大
• 项目类别: Canada Research Chairs
• 财政年份: 2021
• 资助国家: 加拿大
• 起止时间: 2021-01-01 至 2022-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=730205
• 关键词: Prion; Disease; Research

Prion disease such as Creutzfeldt-Jakob disease in humans, mad cow disease or chronic wasting disease (CWD) of cervids are infectious neurodegenerative disorders for which no treatment exists. The zoonotic potential of CWD likely has been underestimated, raising the need for new treatment options. My research program works towards validating novel therapeutic drugs with significant translational potential, and understanding the impact of prions on neuronal metabolism. Elucidating determinants of successful oral or mother-to-offspring transmission of CWD prions will enhance our understanding of prion strain evolution and transmission properties. Overall, my studies serve human, animal and environmental health in Canada and worldwide.

人类的克雅氏病、疯牛病或宫颈慢性衰弱病(CWD)等是感染性神经退行性疾病，目前尚无治疗方法。CWD的人畜共患病潜力可能被低估了，这增加了对新治疗选择的需求。我的研究项目致力于验证具有显著翻译潜力的新型治疗药物，并了解Pron对神经元新陈代谢的影响。阐明CWD病毒在口中或母子之间成功传播的决定因素，将有助于我们更好地理解病毒株的进化和传播特性。总体而言，我的研究服务于加拿大和世界各地的人类、动物和环境健康。