Environmental Physiology And Toxicology

环境生理学和毒理学

• 批准号: CRC-2018-00233
• 负责人: Vijayan, Mathilakath
• 金额: $ 14.57万
• 依托单位: University of Calgary
• 依托单位国家: 加拿大
• 项目类别: Canada Research Chairs
• 财政年份: 2021
• 资助国家: 加拿大
• 起止时间: 2021-01-01 至 2022-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=730462
• 关键词: Environmental; Physiology; Toxicology

My research aims to uncover the molecular mechanisms that allow animals to cope with stress. Specifically, my research will focus on glucocorticoid signalling, a conserved stress coping pathway, which is essential for all aspects of animal growth and welfare. We have genetically edited zebrafish to elucidate the mechanisms involved in stress coping by deleting stress-related genes. These knockout models will allow us to identify emerging contaminants targeting the stress axis and reducing animal fitness. My lab will also determine the mechanisms leading to long-term and multigenerational impacts on stress and growth performances in response to developmental exposure to environmental contaminants.

我的研究旨在揭示动物科普压力的分子机制。具体来说，我的研究将集中在糖皮质激素信号，保守的压力应对途径，这是必不可少的动物生长和福利的各个方面。我们对斑马鱼进行了基因编辑，通过删除压力相关基因来阐明压力应对的机制。这些敲除模型将使我们能够识别针对压力轴和降低动物适应性的新兴污染物。我的实验室还将确定导致长期和多代压力和生长表现的影响，以应对发展暴露于环境污染物的机制。