Understanding and controlling bioavailability: passive dosing of persistent organic pollutants into recombinant cell bioassays

了解和控制生物利用度：重组细胞生物测定中持久性有机污染物的被动给药

• 批准号: DP110101931
• 负责人: Prof Beate Escher
• 金额: $ 11.05万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP110101931
• 关键词: Understanding; controlling; bioavailability; passive; dosing

Bioassays with mammalian cell lines may replace animal testing in chemical risk assessment if issues with limited sensitivity can be overcome for very hydrophobic chemicals such as polychlorinated dibenzodioxins. The project will solve this problem by developing a polymer-release dosing technique that assures defined and constant exposure.

如果能够克服多氯二苯并二恶英等疏水性很强的化学品的敏感性有限的问题，则利用哺乳动物细胞系进行的生物测定可取代化学品风险评估中的动物试验。该项目将通过开发一种聚合物释放剂量技术来解决这一问题，该技术确保确定和恒定的暴露。