Binaural Neural Processing in the Auditory Midbrain

听觉中脑的双耳神经处理

基本信息

  • 批准号:
    RGPIN-2019-06458
  • 负责人:
  • 金额:
    $ 2.04万
  • 依托单位:
  • 依托单位国家:
    加拿大
  • 项目类别:
    Discovery Grants Program - Individual
  • 财政年份:
    2021
  • 资助国家:
    加拿大
  • 起止时间:
    2021-01-01 至 2022-12-31
  • 项目状态:
    已结题

项目摘要

Hearing is dependent on the brain. Our long-term goal is to determine how sounds from an environment are represented in electrical signals generated in the brain and how the representation is dependent on neural circuits, neurochemicals, and neurophysiological processes. Our short-term goal for the next five years is to investigate how a key hearing-related brain structure named the inferior colliculus integrates information obtained at the two ears. A sound from an natural environment can impinge on the left and right ears and generate two stimuli at the ears, respectively. The strengths and timing of the two stimuli are dependent on the location of the sound. Stimulation of the two ears leads to two sets of signals in the left and right auditory neural pathways. These signals are integrated by neurons in the inferior colliculus and other auditory processing centres, so that characteristics of the sound including its spatial location can be gauged by the brain. When multiple sounds exist in an environment, each sound can elicit signals in the auditory neural pathways. Integration of signals elicited by different sounds makes the response to one sound depend on the other, which can greatly affect the perception of each sound. In our research, we will find how a preceding sound generates an aftereffect to shape the response of a neuron to a subsequent sound. We will determine how such an aftereffect is dependent on the spatial relationship between the sounds. We will discover how this dependence is generated as a result of integration of neural signals from the left and right pathways. The rat will be used as an animal model, as it has a keen sense of hearing. Abundant basic knowledge has been obtained about its auditory system. The rat shares basic auditory neural mechanisms with many other mammals. Further research using the rat can enable us to fully understand hearing mechanisms in this species, which will greatly benefit the comprehension of hearing mechanisms in mammals in general. We choose to focus on the inferior colliculus as existing evidence indicates that neurons in this structure are important for the processing of information related to sound quality, timing, and location. Results from our research will help us understand neural mechanisms underlying important aspects of hearing such as localization of sounds and segregation of individual sounds. Comparing our results with existing literature will allow us to identify hearing mechanisms shared by different mammalian species. Thus, this research will significantly advance the field of auditory neuroscience. Knowledge generated from this study about neural processing of temporal changes of spatial acoustic cues can be applied in the future by engineers to develop intelligent hearing-enhancing devices. In addition to generating basic scientific knowledge, this research will provide essential training to students to help them become future leaders in neuroscience research.
听觉依赖于大脑。我们的长期目标是确定来自环境的声音如何在大脑中产生的电信号中表示,以及这种表示如何依赖于神经回路,神经化学物质和神经生理过程。我们未来五年的短期目标是研究一个名为下丘的关键听觉相关大脑结构如何整合双耳获得的信息。来自自然环境的声音可以撞击左耳和右耳,并分别在耳朵处产生两个刺激。这两种刺激的强度和时间取决于声音的位置。刺激两只耳朵会在左右听觉神经通路中产生两组信号。这些信号由下丘和其他听觉处理中心的神经元整合,因此声音的特征,包括其空间位置,可以由大脑测量。当环境中存在多种声音时,每种声音都可以在听觉神经通路中引发信号。由不同声音引起的信号的整合使得对一个声音的响应依赖于另一个声音,这可以极大地影响每个声音的感知。在我们的研究中,我们将发现先前的声音如何产生后效,以塑造神经元对后续声音的反应。我们将确定这种后效如何依赖于声音之间的空间关系。我们将发现这种依赖性是如何作为来自左右通路的神经信号整合的结果而产生的。大鼠将被用作动物模型,因为它具有敏锐的听觉。关于它的听觉系统已经有了丰富的基础知识。大鼠与许多其他哺乳动物共享基本的听觉神经机制。利用大鼠的进一步研究可以使我们能够充分了解这个物种的听觉机制,这将大大有助于理解哺乳动物的听觉机制。我们选择专注于下丘,因为现有的证据表明,这个结构中的神经元对于处理与声音质量,时间和位置相关的信息非常重要。我们的研究结果将帮助我们理解听觉重要方面的神经机制,如声音的定位和单个声音的分离。将我们的研究结果与现有文献进行比较,将使我们能够确定不同哺乳动物物种共享的听觉机制。因此,这项研究将大大推进听觉神经科学领域。从这项研究中产生的知识,空间声学线索的时间变化的神经处理可以应用在未来的工程师开发智能听力增强设备。除了产生基本的科学知识,这项研究将提供必要的培训,以帮助学生成为未来的领导者在神经科学研究。

项目成果

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Zhang, Huiming其他文献

Stereoselective Synthesis of the Halaven C14-C26 Fragment from D-Quinic Acid: Crystallization-Induced Diastereoselective Transformation of an α-Methyl Nitrile
  • DOI:
    10.1002/anie.201501143
  • 发表时间:
    2015-04-20
  • 期刊:
  • 影响因子:
    16.6
  • 作者:
    Belanger, Francis;Chase, Charles E.;Zhang, Huiming
  • 通讯作者:
    Zhang, Huiming
TXR1 and TSP1 expression varies by the molecular subtypes of breast cancer patients who received previous docetaxel-based first-line chemotherapy
  • DOI:
    10.1177/1535370216657443
  • 发表时间:
    2016-11-01
  • 期刊:
  • 影响因子:
    3.2
  • 作者:
    Zhang, Huiming;Qu, Xiang;Wang, Zihan
  • 通讯作者:
    Wang, Zihan
Rhizobacterial volatile emissions regulate auxin homeostasis and cell expansion in Arabidopsis
  • DOI:
    10.1007/s00425-007-0530-2
  • 发表时间:
    2007-09-01
  • 期刊:
  • 影响因子:
    4.3
  • 作者:
    Zhang, Huiming;Kim, Mi-Seong;Pare, Paul W.
  • 通讯作者:
    Pare, Paul W.
Overexpression of long non-coding RNA WT1-AS or silencing of PIK3AP1 are inhibitory to cervical cancer progression
  • DOI:
    10.1080/15384101.2021.1991106
  • 发表时间:
    2021-11-29
  • 期刊:
  • 影响因子:
    4.3
  • 作者:
    Tong, Wenjuan;Zhang, Huiming
  • 通讯作者:
    Zhang, Huiming
Waste cooking oil-to-energy under incomplete information: Identifying policy options through an evolutionary game
  • DOI:
    10.1016/j.apenergy.2016.10.133
  • 发表时间:
    2017-01-01
  • 期刊:
  • 影响因子:
    11.2
  • 作者:
    Zhang, Huiming;Xu, Zhidong;Cao, Jie
  • 通讯作者:
    Cao, Jie

Zhang, Huiming的其他文献

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{{ truncateString('Zhang, Huiming', 18)}}的其他基金

Binaural Neural Processing in the Auditory Midbrain
听觉中脑的双耳神经处理
  • 批准号:
    RGPIN-2019-06458
  • 财政年份:
    2022
  • 资助金额:
    $ 2.04万
  • 项目类别:
    Discovery Grants Program - Individual
Binaural Neural Processing in the Auditory Midbrain
听觉中脑的双耳神经处理
  • 批准号:
    RGPIN-2019-06458
  • 财政年份:
    2020
  • 资助金额:
    $ 2.04万
  • 项目类别:
    Discovery Grants Program - Individual
Binaural Neural Processing in the Auditory Midbrain
听觉中脑的双耳神经处理
  • 批准号:
    RGPIN-2019-06458
  • 财政年份:
    2019
  • 资助金额:
    $ 2.04万
  • 项目类别:
    Discovery Grants Program - Individual
Neural processing of novel sounds
新奇声音的神经处理
  • 批准号:
    341229-2011
  • 财政年份:
    2015
  • 资助金额:
    $ 2.04万
  • 项目类别:
    Discovery Grants Program - Individual
Neural processing of novel sounds
新奇声音的神经处理
  • 批准号:
    341229-2011
  • 财政年份:
    2014
  • 资助金额:
    $ 2.04万
  • 项目类别:
    Discovery Grants Program - Individual
Neural processing of novel sounds
新奇声音的神经处理
  • 批准号:
    341229-2011
  • 财政年份:
    2013
  • 资助金额:
    $ 2.04万
  • 项目类别:
    Discovery Grants Program - Individual
Neural processing of novel sounds
新奇声音的神经处理
  • 批准号:
    341229-2011
  • 财政年份:
    2012
  • 资助金额:
    $ 2.04万
  • 项目类别:
    Discovery Grants Program - Individual
Neural processing of novel sounds
新奇声音的神经处理
  • 批准号:
    341229-2011
  • 财政年份:
    2011
  • 资助金额:
    $ 2.04万
  • 项目类别:
    Discovery Grants Program - Individual
Physiological functions and neural mechanisms of descending projections from the auditory cortex
听觉皮层下降投射的生理功能和神经机制
  • 批准号:
    341229-2008
  • 财政年份:
    2010
  • 资助金额:
    $ 2.04万
  • 项目类别:
    Discovery Grants Program - Individual
Physiological functions and neural mechanisms of descending projections from the auditory cortex
听觉皮层下降投射的生理功能和神经机制
  • 批准号:
    341229-2008
  • 财政年份:
    2009
  • 资助金额:
    $ 2.04万
  • 项目类别:
    Discovery Grants Program - Individual

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  • 批准号:
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  • 批准年份:
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  • 资助金额:
    30 万元
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