Identifying altered gene regulatory network states and underlying mechanisms in atrial fibrillation, a model polygenic disease

识别心房颤动（一种多基因疾病模型）中改变的基因调控网络状态和潜在机制

• 批准号: 472621
• 负责人: De Boer Carl G
• 金额: $ 7.29万
• 依托单位: University of British Columbia
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2022
• 资助国家: 加拿大
• 起止时间: 2022-09-01 至 2023-09-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=472621&lang=en
• 关键词: Atac-Seq; Atrial Fibrillation; Cardiomyocytes; Gene Expression; Gene Regulatory Networks; Gwas; Ipscs; Polygenic Traits; Reporter Assays; Rna-Seq

Common inherited diseases, including heart disease and autoimmunity, are caused by many mutations that occur throughout the genome. These mutations often lie in the parts of the genome adjacent to the genes themselves, and control when and where genes are

常见的遗传性疾病，包括心脏病和自身免疫，是由整个基因组中发生的许多突变引起的。这些突变通常位于基因组中与基因本身相邻的部分，并控制着基因的时间和位置。