Multi-variate and multi-modal modelling of neuroimaging data to better understand brain ageing

神经影像数据的多变量和多模式建模，以更好地了解大脑衰老

• 批准号: RGPIN-2020-05448
• 负责人: Chakravarty, Mallar
• 金额: $ 3.42万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2021
• 资助国家: 加拿大
• 起止时间: 2021-01-01 至 2022-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=740202
• 关键词: Multi; variate; multi; modal; modelling

Understanding variation in ageing requires sophisticated techniques that can examine brain structure and function across  volumetric, microstructural, and functional dimensions. Here, we leverage recent developments from my group for the integration of multi-modal MRI data (using non negative matrix factorization [NMF]) to build models that allow for an improved understanding of how variation in brain structure and function integrate and are related to cognition, with specific focus on the hippocampus. We will use publicly available data (the Human Connectome Project) containing state-of-the-art MRI of brain microstructure related myelin content and axonal properties in addition normative brain function using resting state functional MRI (rsfMRI). We will relate cognitive and functional tasks back to MRI-derived measures. Finally, we will use these techniques in a machine learning-based prediction model for individual age in a well-characterized healthy elderly sample. The goal would be to identify patterns of covariance that best predict cognitive function and age using an integrated analysis strategy that leverages NMF to define components of variance and then to examine the association of each component across cognitive measures using partial least squares (PLS). Compared to common decomposition techniques such as principal and independent component analysis, NMF outputs are more interpretable, sparse, and more spatially contiguous and non overlapping. Research Goals: 1) Microstructural parcellation of the human hippocampus and its relationship with cognition: NMF outputs individual weightings for each subject will be estimated to assess microstructural variability across the 330 unrelated study participants in HCP. Inputs to the NMF will be indices from structural MRI thought to reflect myelin content (T1/T2 ratio) and indices from diffusion MRI (fractional anisotropy and mean diffusivity). Subject-specific component weighting will be related back to 32 cognitive tests administered by the HCP using PLS. 2) Functional parcellation of the human hippocampus and its relationship with cognition: Here we will use a hippocampus-whole-brain approach to derive a rsfMRI based parcellation. Once again the relationship between our parcellation will be related back to the 32 cognitive measures using PLS. 3) Using NMF to predict individual age in a normative population: We will use existing data from the Whitehall II Imaging Sub-study, collected in the FMRIB Centre at Oxford. This dataset includes structural and diffusion MRI, as well as resting-state fMRI scans from 800 community-dwelling adults aged 60-85 years old. The development of an accelerated ageing biomarker has potential relevance to ageing studies in the future focused on heterogeneity of ageing trajectories and developing as a method that can help to better understand the variance in normative ageing. predicting future ageing trajectory.

了解衰老的变化需要复杂的技术，可以在体积、微观结构和功能维度上检查大脑的结构和功能。在这里，我们利用我的团队最近的发展，整合多模态MRI数据（使用非负矩阵分解[NMF]）来构建模型，以便更好地理解大脑结构和功能的变化如何整合并与认知相关，特别关注海马体。我们将使用公开可用的数据（人类连接组项目），其中包含最先进的脑微观结构MRI，包括髓磷脂含量和轴突特性，以及静息状态功能MRI （rsfMRI）的规范脑功能。我们将把认知和功能任务与mri衍生的测量联系起来。最后，我们将在一个基于机器学习的预测模型中使用这些技术，在一个特征良好的健康老年人样本中进行个体年龄预测。目标是使用综合分析策略识别最能预测认知功能和年龄的协方差模式，该策略利用NMF来定义方差的组成部分，然后使用偏最小二乘法（PLS）检查每个组成部分在认知测量中的关联。与常见的分解技术（如主成分分析和独立成分分析）相比，NMF输出更具可解释性、稀疏性，并且在空间上更加连续和不重叠。研究目标：1)人类海马体的微结构包裹及其与认知的关系：NMF输出每个受试者的个体权重将被估计，以评估330名不相关HCP研究参与者的微结构变异性。NMF的输入将是被认为反映髓磷脂含量的结构MRI指标（T1/T2比率）和扩散MRI指标（分数各向异性和平均扩散率）。受试者特定分量权重将与HCP使用PLS进行的32项认知测试相关。2)人类海马的功能包裹及其与认知的关系：在这里，我们将使用海马-全脑方法来获得基于rsfMRI的包裹。再一次，我们的分组之间的关系将与使用PLS的32种认知测量相关。3)使用NMF预测规范人群中的个人年龄：我们将使用来自牛津FMRIB中心收集的白厅II成像子研究的现有数据。该数据集包括来自800名60-85岁社区居民的结构和扩散MRI，以及静息状态功能磁共振成像扫描。加速衰老生物标志物的开发与未来关注衰老轨迹异质性的衰老研究具有潜在的相关性，并可作为一种有助于更好地理解规范衰老差异的方法。预测未来的老龄化轨迹。