Cellular and physiological roles of autophagy-related proteins in Drosophila.
果蝇中自噬相关蛋白的细胞和生理作用。
基本信息
- 批准号:RGPIN-2020-06542
- 负责人:
- 金额:$ 4.23万
- 依托单位:
- 依托单位国家:加拿大
- 项目类别:Discovery Grants Program - Individual
- 财政年份:2021
- 资助国家:加拿大
- 起止时间:2021-01-01 至 2022-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
A biological process called autophagy has garnered enormous attention due to its association with aging, nutrient metabolism, stress, and human diseases. Autophagy literally means "self-eating" and describes a process in which cells degrade parts of themselves for recycling and re-use. This process typically serves to maintain homeostasis but it can also act as an adaptive response, enabling cells to survive conditions of stress such as nutrient deprivation. Autophagy is also involved in numerous developmental processes such as cell growth, tissue remodeling, removal of cell fragments, acquisition of cellular traits and longevity. The core autophagy-related (Atg) proteins required for the autophagy process have been identified in multiple different organisms, but the regulatory inputs and molecular mechanisms by which autophagy carries out its cellular and physiological functions remain ill defined. The long-term goal of my research program is to elucidate the cellular functions and physiological roles of autophagy in normal development in the context of a whole organism. To achieve this goal, my trainees and I will utilize a simple model organism system, the fruit fly, which shares many genetic and cellular components with humans including those required for autophagy. The short-term goal of this proposal is to investigate the influence of sex on the function of autophagy and autophagy-related proteins. Our recent preliminary data, along with emerging evidence in the literature, indicate that sex influences autophagy-related phenotypes. However, the possible influence of sex is largely overlooked in the majority of autophagy investigations, especially since many autophagy studies are conducted in two dimensional cell culture systems. In this study, we will use the fruit fly model system to determine how sex influences autophagy responses and the functions of the core autophagy-related proteins. We will elucidate molecular mechanisms that contribute to sex-specific autophagy-related phenotypes, and be the first to perform a large unbiased screen to identify potential new modifiers of sexually dimorphic autophagy-related phenotypes. Overall, these short term goals will contribute important new knowledge that is fundamental to our long term goal of understanding the physiological roles of the core autophagy-related (Atg) proteins in the context of a whole organism.
一种被称为自噬的生物过程由于其与衰老、营养代谢、压力和人类疾病的关系而引起了人们的极大关注。自噬字面意思是“自食”,描述了细胞降解自身部分以回收和再利用的过程。这个过程通常用于维持体内平衡,但它也可以作为一种适应性反应,使细胞能够在营养缺乏等压力条件下生存。自噬还涉及许多发育过程,如细胞生长、组织重塑、细胞碎片的去除、细胞性状的获得和寿命。自噬过程所需的核心自噬相关(Atg)蛋白已在多种不同的生物体中被鉴定,但自噬执行其细胞和生理功能的调控输入和分子机制仍然不清楚。我的研究计划的长期目标是阐明细胞功能和自噬在整个生物体的正常发育中的生理作用。为了实现这一目标,我和我的学员将利用一个简单的模式生物系统,果蝇,它与人类共享许多遗传和细胞成分,包括自噬所需的成分。 该提案的短期目标是研究性别对自噬和自噬相关蛋白功能的影响。我们最近的初步数据,沿着出现的证据在文献中,表明性别影响自噬相关的表型。然而,在大多数自噬研究中,性别的可能影响在很大程度上被忽视,特别是因为许多自噬研究是在二维细胞培养系统中进行的。在这项研究中,我们将使用果蝇模型系统来确定性别如何影响自噬反应和核心自噬相关蛋白的功能。我们将阐明有助于性别特异性自噬相关表型的分子机制,并成为第一个进行大规模无偏筛选以确定性二态性自噬相关表型的潜在新修饰剂的人。总的来说,这些短期目标将有助于重要的新知识,这对于我们理解核心自噬相关(Atg)蛋白在整个生物体中的生理作用的长期目标至关重要。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
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Gorski, Sharon其他文献
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{{ truncateString('Gorski, Sharon', 18)}}的其他基金
Cellular and physiological roles of autophagy-related proteins in Drosophila.
果蝇中自噬相关蛋白的细胞和生理作用。
- 批准号:
RGPIN-2020-06542 - 财政年份:2022
- 资助金额:
$ 4.23万 - 项目类别:
Discovery Grants Program - Individual
Cellular and physiological roles of autophagy-related proteins in Drosophila.
果蝇中自噬相关蛋白的细胞和生理作用。
- 批准号:
RGPIN-2020-06542 - 财政年份:2020
- 资助金额:
$ 4.23万 - 项目类别:
Discovery Grants Program - Individual
Macroautophagy in Drosophila development
果蝇发育中的巨自噬
- 批准号:
RGPIN-2015-04982 - 财政年份:2019
- 资助金额:
$ 4.23万 - 项目类别:
Discovery Grants Program - Individual
Macroautophagy in Drosophila development
果蝇发育中的巨自噬
- 批准号:
RGPIN-2015-04982 - 财政年份:2018
- 资助金额:
$ 4.23万 - 项目类别:
Discovery Grants Program - Individual
Macroautophagy in Drosophila development
果蝇发育中的巨自噬
- 批准号:
RGPIN-2015-04982 - 财政年份:2017
- 资助金额:
$ 4.23万 - 项目类别:
Discovery Grants Program - Individual
Macroautophagy in Drosophila development
果蝇发育中的巨自噬
- 批准号:
RGPIN-2015-04982 - 财政年份:2016
- 资助金额:
$ 4.23万 - 项目类别:
Discovery Grants Program - Individual
Macroautophagy in Drosophila development
果蝇发育中的巨自噬
- 批准号:
RGPIN-2015-04982 - 财政年份:2015
- 资助金额:
$ 4.23万 - 项目类别:
Discovery Grants Program - Individual
Roles of macroautophagy in Drosophila development
巨自噬在果蝇发育中的作用
- 批准号:
RGPIN-2014-05029 - 财政年份:2014
- 资助金额:
$ 4.23万 - 项目类别:
Discovery Grants Program - Individual
Roles of macroautophagy in drosophila development
巨自噬在果蝇发育中的作用
- 批准号:
371368-2009 - 财政年份:2013
- 资助金额:
$ 4.23万 - 项目类别:
Discovery Grants Program - Individual
Roles of macroautophagy in drosophila development
巨自噬在果蝇发育中的作用
- 批准号:
371368-2009 - 财政年份:2012
- 资助金额:
$ 4.23万 - 项目类别:
Discovery Grants Program - Individual
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