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Tumor-Secreted Nucleosides Can Promote RbFox1 Degradation and Signalling Pathways Relevant to Dedifferentiation in Cardiomyocytes; A Two-Hit Hypothesis with Implications for Cardiotoxicity

Tumor-Secreted Nucleosides Can Promote RbFox1 Degradation and Signalling Pathways Relevant to Dedifferentiation in Cardiomyocytes; A Two-Hit Hypothesis with Implications for Cardiotoxicity
肿瘤分泌核苷可促进 RbFox1 降解以及与心肌细胞去分化相关的信号通路；
批准号：
467633
负责人：
Sutendra Gopinath
金额：
$83.6万
依托单位：
University of Alberta
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2022
资助国家：
加拿大
项目状态：
未结题
起止时间：
2022-09-01 至 2027-09-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=467633&lang=en
关键词：
Apoptosis Susceptibility Dna Damage Heart Failure Mitochondria Oncology Paracrine Signalling Tumor-Secreted Factors

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It is well-documented that tumor cells can secrete numerous signalling factors that affect distant normal tissues. For example, tumor-secreted inflammatory factors can initiate muscle or fat tissue breakdown into protein or fatty acids, respectively, that
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Canada Research Chair - Tier 2
  • 批准号：
    453981
  • 项目类别：
  • 资助金额：
    $43.71万
  • 财政年份：
    2021
  • 负责人：
    Sutendra Gopinath
  • 依托单位：
    University of Alberta
A Stress Activated Znf281 Signalling Pathway Can be Therapeutically Targeted to Prevent Chemotherapy-Induced Cardiotoxicity
  • 批准号：
    451325
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    Operating Grants
  • 资助金额：
    $69.66万
  • 财政年份：
    2021
  • 负责人：
    Sutendra Gopinath
  • 依托单位：
    University of Alberta
Activation of Pyruvate Kinase M2 as a Novel Therapy for Chemotherapy-Induced Cardiotoxicity
  • 批准号：
    355953
  • 项目类别：
    Operating Grants
  • 资助金额：
    $58.24万
  • 财政年份：
    2016
  • 负责人：
    Sutendra Gopinath
  • 依托单位：
    University of Alberta
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