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The glycerol shunt and nutrient excess detoxification in the pancreatic ß-cell and liver

The glycerol shunt and nutrient excess detoxification in the pancreatic ß-cell and liver
胰腺细胞和肝脏中的甘油分流和营养过剩解毒
批准号：
469691
负责人：
Prentki Marc
金额：
$67.99万
依托单位：
Centre hospitalier de l'Universit de Montral (CHUM)
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2022
资助国家：
加拿大
项目状态：
未结题
起止时间：
2022-09-01 至 2027-09-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=469691&lang=en
关键词：
Glycerol Shunt Glycerol-3-Phosphate Phosphatase Hepatocytes Insulin Secretion Lipid Metabolism Non-Alcoholic Fatty Liver Disease Obesity Pancreatic Beta Cell Protein-Protein Interactions Type 2 Diabetes

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Incidences of obesity, type 2 diabetes (T2D) and fatty liver disease are increasing worldwide and these diseases are major contributors of morbidity and mortality. Excess intake of nutrient fuels, including carbohydrates, proteins and fats, can disturb th
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