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Metabolic deceleration as a mechanism for the anti-diabetic effects of metformin and berberine

Metabolic deceleration as a mechanism for the anti-diabetic effects of metformin and berberine
代谢减速是二甲双胍和小檗碱抗糖尿病作用的机制
批准号：
262677
负责人：
Prentki Marc
金额：
$16.39万
依托单位：
Centre hospitalier de l'Universit de Montral (CHUM)
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2012
资助国家：
加拿大
项目状态：
已结题
起止时间：
2012-05-01 至 2015-05-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=262677&lang=en
关键词：
Berberine Détoxification Fatty Acids Glucolipotoxicity Lipolysis Metabolic Deceleration Metformin Mitochondrial Complex-I Pancreatic Beta Cell Type 2 Diabetes

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英文摘要
Excess supply of nutrient fuels, viz., carbohydrates, proteins and fats, can lead to toxicity by disturbing the normal cellular functions in the body, resulting in obesity and diabetes. Thus, continuous exposure of pancreatic beta cells to high fat and gl
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